Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

被引：0

作者：

Danwei Huangfu

René Maehr

Wenjun Guo

Astrid Eijkelenboom

Melinda Snitow

Alice E Chen

Douglas A Melton

机构：

[1] Howard Hughes Medical Institute,Department of Stem Cell and Regenerative Biology

[2] Harvard Stem Cell Institute,undefined

[3] Harvard University,undefined

[4] Whitehead Institute for Biomedical Research,undefined

[5] Biomedical Sciences,undefined

[6] Utrecht University,undefined

来源：

Nature Biotechnology | 2008年 / 26卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Existing methods for reprogramming somatic cells to 'induced pluripotent stem cells' are inefficient, with only a small fraction of the starting cell population becoming pluripotent. Working with mouse embryonic fibroblasts, Hunagfu et al. increase reprogramming efficiency by treatment with DNA methyltransferase and histone deacetylase inhibitors.

引用

页码：795 / 797

页数：2

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