Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds

被引：0
|
作者：
Danwei Huangfu
René Maehr
Wenjun Guo
Astrid Eijkelenboom
Melinda Snitow
Alice E Chen
Douglas A Melton
机构：
[1] Howard Hughes Medical Institute,Department of Stem Cell and Regenerative Biology
[2] Harvard Stem Cell Institute,undefined
[3] Harvard University,undefined
[4] Whitehead Institute for Biomedical Research,undefined
[5] Biomedical Sciences,undefined
[6] Utrecht University,undefined
来源：
Nature Biotechnology | 2008年 / 26卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Existing methods for reprogramming somatic cells to 'induced pluripotent stem cells' are inefficient, with only a small fraction of the starting cell population becoming pluripotent. Working with mouse embryonic fibroblasts, Hunagfu et al. increase reprogramming efficiency by treatment with DNA methyltransferase and histone deacetylase inhibitors.
引用
收藏
页码：795 / 797
页数：2
相关论文
共 50 条
  • [1] Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds
    Huangfu, Danwei
    Maehr, Rene
    Guo, Wenjun
    Eijkelenboom, Astrid
    Snitow, Melinda
    Chen, Alice E.
    Melton, Douglas A.
    NATURE BIOTECHNOLOGY, 2008, 26 (07) : 795 - 797
  • [2] Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds
    Hou, Pingping
    Li, Yanqin
    Zhang, Xu
    Liu, Chun
    Guan, Jingyang
    Li, Honggang
    Zhao, Ting
    Ye, Junqing
    Yang, Weifeng
    Liu, Kang
    Ge, Jian
    Xu, Jun
    Zhang, Qiang
    Zhao, Yang
    Deng, Hongkui
    SCIENCE, 2013, 341 (6146) : 651 - 654
  • [3] In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction
    Osakada, Fumitaka
    Jin, Zi-Bing
    Hirami, Yasuhiko
    Ikeda, Hanako
    Danjyo, Teruko
    Watanabe, Kiichi
    Sasai, Yoshiki
    Takahashi, Masayo
    JOURNAL OF CELL SCIENCE, 2009, 122 (17) : 3169 - 3179
  • [4] Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds
    Shi, Yan
    Desponts, Caroline
    Do, Jeong Tae
    Hahm, Heung Sik
    Schoeler, Hans R.
    Ding, Sheng
    CELL STEM CELL, 2008, 3 (05) : 568 - 574
  • [5] Simple and Robust Differentiation of Human Pluripotent Stem Cells toward Chondrocytes by Two Small-Molecule Compounds
    Kawata, Manabu
    Mori, Daisuke
    Kanke, Kosuke
    Hojo, Hironori
    Ohba, Shinsuke
    Chung, Ung-il
    Yano, Fumiko
    Masaki, Hideki
    Otsu, Makoto
    Nakauchi, Hiromitsu
    Tanaka, Sakae
    Saito, Taku
    STEM CELL REPORTS, 2019, 13 (03): : 530 - 544
  • [6] Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells
    Se-Woong Oh
    Jung Bok Lee
    Bora Kim
    Sejin Jeon
    Min-Kyoung Kim
    Ki-Hoan Nam
    Jong-Ryul Ha
    Mickie Bhatia
    Goo Taeg Oh
    Dae-Yong Kim
    Archives of Pharmacal Research, 2012, 35 : 1979 - 1988
  • [7] Peptidomimetic small-molecule compounds promoting cardiogenesis of stem cells
    Oh, Se-Woong
    Lee, Jung Bok
    Kim, Bora
    Jeon, Sejin
    Kim, Min-Kyoung
    Nam, Ki-Hoan
    Ha, Jong-Ryul
    Bhatia, Mickie
    Oh, Goo Taeg
    Kim, Dae-Yong
    ARCHIVES OF PHARMACAL RESEARCH, 2012, 35 (11) : 1979 - 1988
  • [8] Small-Molecule Induction Promotes Corneal Epithelial Cell Differentiation from Human Induced Pluripotent Stem Cells
    Mikhailova, Alexandra
    Ilmarinen, Tanja
    Uusitalo, Hannu
    Skottman, Heli
    STEM CELL REPORTS, 2014, 2 (02): : 219 - 231
  • [9] Growth Factors and Small-molecule Compounds in Derivation of Endothelial Lineages from Dental Stem Cells
    Yi, Baicheng
    Dissanayaka, Waruna Lakmal
    Zhang, Chengfei
    JOURNAL OF ENDODONTICS, 2020, 46 (09) : S63 - S70
  • [10] A small-molecule label for stem cells
    Nature Methods, 2014, 11 (5) : 476 - 476
12345