Synthesis and biological activity of new pyranochromen-3-carboxamides

被引：0
|
作者：
R. V. Shutov
E. V. Kuklina
N. A. Anisimova
E. P. Anan’ev
N. I. Kotova
V. N. Kuklin
机构：
[1] St. Petersburg State Chemico-Pharmaceutical Academy,
来源：
Pharmaceutical Chemistry Journal | 2012年 / 46卷
关键词：
pyranochromen-3-carboxamides; 3-formylchromones; synthesis; structure; analgesic; anxiolytic; and antimicrobial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A series of new pyranochromen-3-carboxamides have been synthesized in good yield by reacting 2-phenyl-4-hydroxy-6H-1,3-thiazin-6-ones with substituted 3-formylchromones. Pharmacological screening showed an influence of the substituent in the 9-position of the pyranochromen-3-carboxamides on the acute toxicity and antifungal, analgesic, and anxiolytic activity. 9-Bromo-2H,5H-pyranochromen-3-carboxamide can be recommended for further pharmacological investigation.
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页码：10 / 14
页数：4
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