SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW ISOXAZOLYL DIBENZAZEPINE CARBOXAMIDES

被引：0
|
作者：
Kaur, Ranjit
Rao, Gopal Krishna [1 ]
Pai, P. N. Sanjay [2 ]
机构：
[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India
[2] Al Ameen Coll Pharm, Dept Qual Assurance, Bangalore 560027, Karnataka, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 20卷 / 03期
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D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of isoxazolyl-5H-dibenzo [b,f] azepine-5-carboxamides (3a-i) were synthesized using N-[4-(3-arylacryloyl) phenyl]-5H-dibenzo [b, f] azepine-5-carboxamide and hydroxylamine hydrochloride in presence of ethanol and potassium hydroxide. The structures were confirmed by their IR, (1)H and (13)C NMR, Mass and CHN analysis data. All the derivatives have been evaluated for their antibacterial activity by cup plate method and antitubercular activity by microbroth dilution method. Some of the derivatives have shown moderate to good biological activity.
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页码：299 / 300
页数：2
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