SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW ISOXAZOLYL DIBENZAZEPINE CARBOXAMIDES

被引：0
|
作者：
Kaur, Ranjit
Rao, Gopal Krishna [1 ]
Pai, P. N. Sanjay [2 ]
机构：
[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India
[2] Al Ameen Coll Pharm, Dept Qual Assurance, Bangalore 560027, Karnataka, India
来源：
INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2011年 / 20卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of isoxazolyl-5H-dibenzo [b,f] azepine-5-carboxamides (3a-i) were synthesized using N-[4-(3-arylacryloyl) phenyl]-5H-dibenzo [b, f] azepine-5-carboxamide and hydroxylamine hydrochloride in presence of ethanol and potassium hydroxide. The structures were confirmed by their IR, (1)H and (13)C NMR, Mass and CHN analysis data. All the derivatives have been evaluated for their antibacterial activity by cup plate method and antitubercular activity by microbroth dilution method. Some of the derivatives have shown moderate to good biological activity.
引用
收藏
页码：299 / 300
页数：2
相关论文
共 50 条
  • [41] Synthesis and Characterization of Some New Salicylamide Derivatives with Potential Biological Activity
    Ienascu, Ioana M. C.
    Padure, Mirabela A.
    Lupea, Alfa Xenia
    Balcu, Ionel
    Popescu, Iuliana M.
    REVISTA DE CHIMIE, 2010, 61 (04): : 368 - 371
  • [42] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW HETEROCYCLIC QUINOLINE DERIVATIVES
    AWAD, IMA
    ABDELRAHMAN, AE
    BAKHITE, EA
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1991, 57 (3-4) : 293 - 301
  • [43] Synthesis and Biological Activity of Some New Pyrazole Copper(II) Complexes
    Maruoka, Hiroshi
    Nishida, Sho
    Kashige, Nobuhiro
    Yoshimura, Yuki
    Omori, Masahiko
    Tomita, Ryoko
    Masumoto, Eiichi
    Okabe, Fumi
    Miake, Fumio
    Yamagata, Kenji
    Fujioka, Toshihiro
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (05) : 1218 - 1223
  • [44] Synthesis of Some New Polycyclic Heterocyclic Compounds of Anticipated Biological Activity
    Alsufyani, Taghreed A.
    Saad, Hosam A.
    Al-otaibi, Asmaa A. A.
    LETTERS IN ORGANIC CHEMISTRY, 2021, 18 (03) : 240 - 249
  • [45] Synthesis and studies on the biological activity of some new spiro heterocyclic compounds
    Khalafallah, AK
    Koraiem, AIM
    AbuDooh, AM
    Shindy, HA
    Elmagid, NA
    ASIAN JOURNAL OF CHEMISTRY, 1996, 8 (03) : 529 - 535
  • [46] Synthesis of some new thio uracil derivatives with expected biological activity
    Fathalla, OA
    AFINIDAD, 2001, 58 (494) : 269 - 275
  • [47] Synthesis and Biological Activity Test of Some New Five Membered Heterocycles
    Xia Qingchun
    Xu Dongfang
    He Qizhuang
    Li Xingyu
    Sun Dazhi
    CHINESE JOURNAL OF CHEMISTRY, 2010, 28 (12) : 2433 - 2440
  • [48] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW SUBSTITUTED PYRAZOLINES AND ISOXAZOLINES
    SHINGARE, MS
    SIDDIQUI, HB
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1989, 28 (02): : 154 - 158
  • [49] Synthesis and biological activity of some new 4-thiazolidinone derivatives
    Trivedi, VP
    Undavia, NK
    Trivedi, PB
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2004, 81 (06) : 506 - 508
  • [50] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SOME NEW NUCLEOSIDES RESEMBLING GUANOSINE
    ROBINS, RK
    SIMON, LN
    SIDWELL, RW
    COOK, PD
    WITKOWSKI, JT
    REVANKAR, GR
    TRANSACTIONS OF THE NEW YORK ACADEMY OF SCIENCES, 1974, 36 (07): : 706 - 706
12345