Haematopoietic stem cell self-renewal in vivo and ex vivo

被引：0
|
作者：
Adam C. Wilkinson
Kyomi J. Igarashi
Hiromitsu Nakauchi
机构：
[1] Stanford University School of Medicine,Institute for Stem Cell Biology and Regenerative Medicine
[2] Stanford University School of Medicine,Department of Genetics
[3] The University of Tokyo,Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science
来源：
Nature Reviews Genetics | 2020年 / 21卷
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摘要：
The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.
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页码：541 / 554
页数：13
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