Haematopoietic stem cell self-renewal in vivo and ex vivo

被引：0
|
作者：
Adam C. Wilkinson
Kyomi J. Igarashi
Hiromitsu Nakauchi
机构：
[1] Stanford University School of Medicine,Institute for Stem Cell Biology and Regenerative Medicine
[2] Stanford University School of Medicine,Department of Genetics
[3] The University of Tokyo,Division of Stem Cell Therapy, Distinguished Professor Unit, The Institute of Medical Science
来源：
Nature Reviews Genetics | 2020年 / 21卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The self-renewal capacity of multipotent haematopoietic stem cells (HSCs) supports blood system homeostasis throughout life and underlies the curative capacity of clinical HSC transplantation therapies. However, despite extensive characterization of the HSC state in the adult bone marrow and embryonic fetal liver, the mechanism of HSC self-renewal has remained elusive. This Review presents our current understanding of HSC self-renewal in vivo and ex vivo, and discusses important advances in ex vivo HSC expansion that are providing new biological insights and offering new therapeutic opportunities.
引用
收藏
页码：541 / 554
页数：13
相关论文
共 50 条
  • [31] Stem cell self-renewal and cancer
    Morrison, Sean J.
    CANCER RESEARCH, 2014, 74 (19)
  • [32] Neural stem cell self-renewal
    Shi, Yanhong
    Sun, Guoqiang
    Zhao, Chunnian
    Stewart, Richard
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2008, 65 (01) : 43 - 53
  • [33] Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy
    Nakada, Daisuke
    Oguro, Hideyuki
    Levi, Boaz P.
    Ryan, Nicole
    Kitano, Ayumi
    Saitoh, Yusuke
    Takeichi, Makiko
    Wendt, George R.
    Morrison, Sean J.
    NATURE, 2014, 505 (7484) : 555 - +
  • [34] Hematopoietic stem cell self-renewal
    Akala, Omobolaji O.
    Clarke, Michael F.
    CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (05) : 496 - 501
  • [35] The regulation of stem cell self-renewal
    Morrison, Sean J.
    FASEB JOURNAL, 2008, 22
  • [36] Self-renewal and differentiation at Cell Stem Cell
    Zon, Leonard I.
    CELL STEM CELL, 2008, 2 (06) : 510 - 510
  • [37] Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
    Fleming, Heather E.
    Janzen, Viktor
    Lo Celso, Cristina
    Guo, Jun
    Leahy, Kathleen M.
    Kronenberg, Henry M.
    Scadden, David T.
    CELL STEM CELL, 2008, 2 (03) : 274 - 283
  • [38] Self-renewal and differentiation potential of reactive astrocytes in vivo
    Canhos, L.
    Falk, S.
    Sirko, S.
    Goetz, M.
    GLIA, 2017, 65 : E121 - E121
  • [39] MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
    Vincenzo Calvanese
    Andrew T. Nguyen
    Timothy J. Bolan
    Anastasia Vavilina
    Trent Su
    Lydia K. Lee
    Yanling Wang
    Fides D. Lay
    Mattias Magnusson
    Gay M. Crooks
    Siavash K. Kurdistani
    Hanna K. A. Mikkola
    Nature, 2019, 576 : 281 - 286
  • [40] MLLT3 governs human haematopoietic stem-cell self-renewal and engraftment
    Calvanese, Vincenzo
    Nguyen, Andrew T.
    Bolan, Timothy J.
    Vavilina, Anastasia
    Su, Trent
    Lee, Lydia K.
    Wang, Yanling
    Lay, Fides D.
    Magnusson, Mattias
    Crooks, Gay M.
    Kurdistani, Siavash K.
    Mikkola, Hanna K. A.
    NATURE, 2019, 576 (7786) : 281 - +
12345