Evaluation of Enzymatic Activities in Living Systems with Small-molecular Fluorescent Substrate Probes

被引：0
|
作者：
Toru Komatsu
Yasuteru Urano
机构：
[1] The University of Tokyo,Graduate School of Pharmaceutical Sciences
[2] The University of Tokyo,Graduate School of Medicine
[3] JST PRESTO,undefined
来源：
Analytical Sciences | 2015年 / 31卷
关键词：
Enzymes; fluorescent substrates; fluorescence imaging; medicinal chemistry; chemical biology;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
In this review, we aim to present an overview of how small-molecular fluorescent substrate probes for studying enzymatic functions are developed and how they are used in biological applications, under the following four headings: (1) History of Visual Detection of Enzymatic Activities, (2) Strategies to Design Fluorescent Substrate Probes to Measure Enzymatic Activities, (3) Development of Fluorescent Substrate Probes Suitable for Biological Studies, and (4) Biological Applications of Fluorescent Substrate Probes for Studying Enzymes.
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页码：257 / 265
页数：8
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