Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

被引：0
|
作者：
Eros Lazzerini Denchi
Titia de Lange
机构：
[1] Laboratory for Cell Biology and Genetics,
[2] The Rockefeller University,undefined
[3] 1230 York Avenue,undefined
[4] New York,undefined
[5] New York 10021,undefined
[6] USA,undefined
来源：
Nature | 2007年 / 448卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The telomeres that cap normal chromosomes share virtually the same structure as damaged DNA sequences within chromosomes. So how do telomeres evade recognition by the DNA-repair machinery? Simple: two telomere binding proteins, TRF2 and POT1, block the activation of two key DNA damage response pathways. With TRF2 and POT1 inactivated, telomeres can be 'repaired' into the chromosomes where they don't belong.
引用
收藏
页码：1068 / 1071
页数：3
相关论文
共 50 条
  • [21] TRF2-Tethered TIN2 Can Mediate Telomere Protection by TPP1/POT1
    Frescas, David
    de lange, Titia
    MOLECULAR AND CELLULAR BIOLOGY, 2014, 34 (07) : 1349 - 1362
  • [22] Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
    Broccoli, D.
    Smogorzewska, A.
    Chong, L.
    De Lange, T.
    Tectonophysics, 277 (1-3):
  • [23] A rare missense variant in protection of telomeres 1 (POT1) predisposes to a range of haematological malignancies
    Nathan, Vaishnavi
    Johansson, Peter A.
    Palmer, Jane M.
    Hamilton, Hayley R.
    Howlie, Madeleine
    Brooks, Kelly M.
    Hayward, Nicholas K.
    Pritchard, Antonia L.
    BRITISH JOURNAL OF HAEMATOLOGY, 2021, 192 (02) : E57 - E60
  • [24] PROTECTION OF TELOMERES 1 (POT1) REGULATES HEMATOPOIETIC STEM CELL ACTIVITY DURING AGEING
    Hosokawa, Kentaro
    MacArthur, Ben D.
    Hanazawa, Shigemasa
    Suda, Toshio
    Arai, Fumio
    EXPERIMENTAL HEMATOLOGY, 2015, 43 (09) : S68 - S68
  • [25] Human Pot1 (Protection of telomeres) protein: Cytolocalization, gene structure, and alternative splicing
    Baumann, P
    Podell, E
    Cech, TR
    MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (22) : 8079 - 8087
  • [26] QUERCETIN REGULATES TELOMERE-BINDING PROTEINS EXPRESSION OF POT1, TRF1, TRF2 TO INHIBIT PROLIFERATION AND INDUCE APOPTOSIS IN AML THP-1 CELLS
    Cui, S.
    Wu, X.
    Wang, Z.
    Guo, Y.
    Xu, R.
    HAEMATOLOGICA, 2017, 102 : 674 - 674
  • [27] Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2
    Broccoli, D
    Smogorzewska, A
    Chong, L
    deLange, T
    NATURE GENETICS, 1997, 17 (02) : 231 - 235
  • [28] TRF1、TRF2及POT1 mRNA在前列腺癌组织中的表达及临床意义
    王英磊
    张莹莹
    孟琳
    肖琳
    范成娟
    李磊
    张任亚
    赵战魁
    中国老年学杂志, 2016, 36 (21) : 5234 - 5235
  • [29] Altered mRNA expression of telomere binding proteins (TPP1, POT1, RAP1, TRF1 and TRF2) in ulcerative colitis and Crohn's disease
    Da-Silva, Nancy
    Arasaradnam, Ramesh
    Getliffe, Katherine
    Sung, Edward
    Oo, Ye
    Nwokolo, Chuka
    DIGESTIVE AND LIVER DISEASE, 2010, 42 (08) : 544 - 548
  • [30] SHELTERIN COMPONENT PROTECTION OF TELOMERES 1 (POT1) PLAYS A CRITICAL ROLE IN THE SELF-RENEWAL OF HSCS
    Hosokawa, Kentaro
    Suda, Toshio
    Arai, Fumio
    EXPERIMENTAL HEMATOLOGY, 2013, 41 (08) : S37 - S37
12345