Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

被引：0
|
作者：
Eros Lazzerini Denchi
Titia de Lange
机构：
[1] Laboratory for Cell Biology and Genetics,
[2] The Rockefeller University,undefined
[3] 1230 York Avenue,undefined
[4] New York,undefined
[5] New York 10021,undefined
[6] USA,undefined
来源：
Nature | 2007年 / 448卷
关键词：
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学科分类号：
摘要：
The telomeres that cap normal chromosomes share virtually the same structure as damaged DNA sequences within chromosomes. So how do telomeres evade recognition by the DNA-repair machinery? Simple: two telomere binding proteins, TRF2 and POT1, block the activation of two key DNA damage response pathways. With TRF2 and POT1 inactivated, telomeres can be 'repaired' into the chromosomes where they don't belong.
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页码：1068 / 1071
页数：3
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