Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse

被引：3

作者：

Piccinin, Elena ^{[1
]}

Arconzo, Maria ^{[2
]}

Graziano, Giusi ^{[2
]}

Vacca, Michele ^{[3
]}

Peres, Claudia ^{[2
]}

Bellafante, Elena ^{[4
]}

Villani, Gaetano ^{[5
]}

Moschetta, Antonio ^{[1
,2
]}

机构：

[1] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy

[2] Natl Inst Biostuct & Biosyst, INBB, I-00136 Rome, Italy

[3] Addenbrookes Hosp, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Box 289, Cambridge CB2 0QQ, England

[4] Fdn Mario Negri Sud, I-66030 Chieti, Italy

[5] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期

关键词：

liver metabolism; liver diseases; coactivators; PGC-1; microRNA; ACTIVATED RECEPTOR-GAMMA; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL BIOGENESIS; COACTIVATOR PGC-1-ALPHA; CIRCULATING MICRORNAS; INDUCIBLE COACTIVATOR; URSODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR; CELLULAR SENESCENCE;

D O I：

10.3390/ijms20225735

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-gamma coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.

引用

页数：18

共 50 条

[41] Modular Evolution of PGC-1α in Vertebrates
Christophe M. R. LeMoine
Stephen C. Lougheed
Christopher D. Moyes
Journal of Molecular Evolution, 2010, 70 : 492 - 505
[42] Clking on PGC-1α to Inhibit Gluconeogenesis
Canto, Carles
Auwerx, Johan
CELL METABOLISM, 2010, 11 (01) : 6 - 7
[43] PGC-1 Proteins and Heart Failure
Riehle, Christian
Abel, E. Dale
TRENDS IN CARDIOVASCULAR MEDICINE, 2012, 22 (04) : 98 - 105
[44] Targeting PGC-1α to energy homeostasis
Wu, Zhidan
Boss, Olivier
EXPERT OPINION ON THERAPEUTIC TARGETS, 2007, 11 (10) : 1329 - 1338
[45] Modular Evolution of PGC-1α in Vertebrates
LeMoine, Christophe M. R.
Lougheed, Stephen C.
Moyes, Christopher D.
JOURNAL OF MOLECULAR EVOLUTION, 2010, 70 (05) : 492 - 505
[46] PGC-1α与糖脂代谢
赵文惠
杨文英
国外医学内分泌学分册., 2005, (05) : 355 - 357
[47] The metabolic modulator PGC-1α in cancer
Bost, Frederic
Kaminski, Lisa
AMERICAN JOURNAL OF CANCER RESEARCH, 2019, 9 (02): : 198 - 211
[48] Bioenergetic analysis of peroxisome proliferator-activated receptor γ coactivators 1α and 1β (PGC-1α and PGC-1β) in muscle cells
St-Pierre, J
Lin, J
Krauss, S
Tarr, PT
Yang, RJ
Newgard, CB
Spiegelman, BM
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (29) : 26597 - 26603
[49] Photoreceptor sensitivity to oxidative stress can by regulated by non-redundant roles of PGC-1α and PGC-1β
Abrahan, Carolina Elizabeth
Ash, John D.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2014, 55 (13)
[50] PGC-1α REGULATION OF NEURONAL ENERGY METABOLISM IN MOUSE HIPPOCAMPUS
Anderson, R.
GERONTOLOGIST, 2014, 54 : 163 - 163

← 1 2 3 4 5 →