Hepatic MicroRNA Expression by PGC-1α and PGC-1β in the Mouse

被引：3

作者：

Piccinin, Elena ^{[1
]}

Arconzo, Maria ^{[2
]}

Graziano, Giusi ^{[2
]}

Vacca, Michele ^{[3
]}

Peres, Claudia ^{[2
]}

Bellafante, Elena ^{[4
]}

Villani, Gaetano ^{[5
]}

Moschetta, Antonio ^{[1
,2
]}

机构：

[1] Univ Bari Aldo Moro, Dept Interdisciplinary Med, Piazza Giulio Cesare 11, I-70124 Bari, Italy

[2] Natl Inst Biostuct & Biosyst, INBB, I-00136 Rome, Italy

[3] Addenbrookes Hosp, Metab Res Labs, Wellcome Trust MRC Inst Metab Sci, Box 289, Cambridge CB2 0QQ, England

[4] Fdn Mario Negri Sud, I-66030 Chieti, Italy

[5] Aldo Moro Univ Bari, Dept Basic Med Sci Neurosci & Sense Organs, I-70124 Bari, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 22期

关键词：

liver metabolism; liver diseases; coactivators; PGC-1; microRNA; ACTIVATED RECEPTOR-GAMMA; HEPATOCELLULAR-CARCINOMA; NONALCOHOLIC STEATOHEPATITIS; MITOCHONDRIAL BIOGENESIS; COACTIVATOR PGC-1-ALPHA; CIRCULATING MICRORNAS; INDUCIBLE COACTIVATOR; URSODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR; CELLULAR SENESCENCE;

D O I：

10.3390/ijms20225735

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-gamma coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.

引用

页数：18

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