Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil

被引：32

作者：

Rodrigues, VDFS

Telles, MA

Ribeiro, MO

Cafrune, PU

Rossetti, MLR

Zaha, A

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Estado Rio Grande Sul, BR-91501970 Porto Alegre, RS, Brazil

[3] FEPPS, CDCT, Porto Alegre, RS, Brazil

[4] Inst Adolfo Lutz Registro, Lab Bacteriol Tuberculose, Sao Paulo, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 01期

关键词：

D O I：

10.1128/AAC.49.1.444-446.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

引用

页码：444 / 446

页数：3

共 50 条

[41] Characterization of pncA mutations in multi-drug and pyrazinamide resistant Mycobacterium tuberculosis isolates cultured from Queensland migrants and Papua New Guinea residents
Pandey, Sushil
Lavu, Evelyn
Congdon, Jacob
Moke, Rendi
Bainomugisa, Arnold
Coulter, Christopher
TUBERCULOSIS, 2018, 111 : 109 - 113
[42] Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan
Muhammad Tahir khan
Shaukat Iqbal Malik
Sajid Ali
Nayyer Masood
Tariq Nadeem
Anwar Sheed Khan
Muhammad Tanvir Afzal
BMC Infectious Diseases, 19
[43] Association between pncA Gene Mutations, Pyrazinamidase Activity, and Pyrazinamide Susceptibility Testing in Mycobacterium tuberculosis
Aono, Akio
Chikamatsu, Kinuyo
Yamada, Hiroyuki
Kato, Tomoko
Mitarai, Satoshi
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (08) : 4928 - 4930
[44] Pyrazinamide resistance and mutations in pncA among isolates of Mycobacterium tuberculosis from Khyber Pakhtunkhwa, Pakistan
Khan, Muhammad Tahir
Malik, Shaukat Iqbal
Ali, Sajid
Masood, Nayyer
Nadeem, Tariq
Khan, Anwar Sheed
Afzal, Muhammad Tanvir
BMC INFECTIOUS DISEASES, 2019, 19 (1)
[45] Mutation in pncA is a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis
Hirano, K
Takahashi, M
Kazumi, Y
Fukasawa, Y
Abe, C
TUBERCLE AND LUNG DISEASE, 1998, 78 (02): : 117 - 122
[46] Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance
Shrestha, Dipti
Maharjan, Bhagwan
Thapa, Jeewan
Akapelwa, Mwangala Lonah
Bwalya, Precious
Chizimu, Joseph Yamweka
Nakajima, Chie
Suzuki, Yasuhiko
CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (09) : 4132 - 4141
[47] Pyrazinamide Susceptibility and pncA Mutation Profiles of Mycobacterium tuberculosis among Multidrug-Resistant Tuberculosis Patients in Bangladesh
Rahman, Arfatur
Ferdous, Sara Sabrina
Ahmed, Shahriar
Rahman, S. M. Mazidur
Uddin, Mohammad Khaja Mafij
Pholwat, Suporn
Gratz, Jean
Houpt, Eric
Banu, Sayera
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (09)
[48] The epidemiology and gene mutation characteristics of pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates in Southern China
Wang, Nan
Meng, Fanrong
Deng, Li
Wu, Ling
Yang, Yu
Li, Hua
Chen, Yuanjin
Wei, Zeyou
Xie, Bei
Gong, Lan
Niu, Qun
Lei, Jie
Gao, Junwen
Huang, Bo
Wang, Qi
Lai, Xiaomin
Liu, Zhihui
Hu, Jinxing
EMERGING MICROBES & INFECTIONS, 2025, 14 (01)
[49] Treatment Outcomes of Pulmonary Pyrazinamide-Resistant Multidrug-Resistant Tuberculosis
Park, S.
Ji, W.
Jo, K.
Shim, T.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
[50] A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
Shahab, Muhammad
de Farias Morais, Gabriel Christian
Akash, Shopnil
Fulco, Umberto Laino
Oliveira, Jonas Ivan Nobre
Zheng, Guojun
Akter, Shahina
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2024, 28 (08)

← 1 2 3 4 5 →