Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil

被引：32

作者：

Rodrigues, VDFS

Telles, MA

Ribeiro, MO

Cafrune, PU

Rossetti, MLR

Zaha, A

机构：

[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Estado Rio Grande Sul, BR-91501970 Porto Alegre, RS, Brazil

[3] FEPPS, CDCT, Porto Alegre, RS, Brazil

[4] Inst Adolfo Lutz Registro, Lab Bacteriol Tuberculose, Sao Paulo, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 01期

关键词：

D O I：

10.1128/AAC.49.1.444-446.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.

引用

页码：444 / 446

页数：3

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