Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis in Brazil

被引：32
|
作者：
Rodrigues, VDFS
Telles, MA
Ribeiro, MO
Cafrune, PU
Rossetti, MLR
Zaha, A
机构：
[1] Univ Fed Rio Grande do Sul, Ctr Biotecnol, BR-91501970 Porto Alegre, RS, Brazil
[2] Univ Fed Rio Grande do Sul, Estado Rio Grande Sul, BR-91501970 Porto Alegre, RS, Brazil
[3] FEPPS, CDCT, Porto Alegre, RS, Brazil
[4] Inst Adolfo Lutz Registro, Lab Bacteriol Tuberculose, Sao Paulo, Brazil
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 01期
关键词：
D O I：
10.1128/AAC.49.1.444-446.2005
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this study the nucleotide sequence of the pncA gene from 59 Mycobacterium tuberculosis clinical isolates was analyzed. Mutations in the pncA gene were identified in 29 of 40 pyrazinamide-resistant isolates, and no pyrazinamidase activity was detected in 39 of them. Twelve mutations found in this work have not been described previously.
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收藏
页码：444 / 446
页数：3
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