Synthesis and Antibacterial Evaluation of Thiouracil Derivatives Contain-ing 1,2,4-Triazolo[1,5-a]Pyrimidine

被引：1
|
作者：
Cui, Penglei [1 ]
Zhang, Di [2 ]
Guo, Xiumin [1 ]
Ji, Shujing [1 ]
Jiang, Qingmei [1 ]
机构：
[1] Hebei Agr Univ, Coll Sci, Baoding 071001, Peoples R China
[2] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Peoples R China
来源：
LETTERS IN ORGANIC CHEMISTRY | 2021年 / 18卷 / 07期
关键词：
Thiouracil; antibacterial activity; triazole; pyrimidine; synthesis; norfloxacin; SECA; DESIGN; INHIBITOR; ANALOGS;
D O I：
10.2174/1570178617999200826164227
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new thiouracil compounds containing 1,2,4-triazolo[1,5-a]pyrimidine were designed and synthesized. The in vitro antibacterial activities of the new compounds against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis were tested. The results showed that some of the new compounds had strong inhibitory activities against the tested bacteria. At the concentration of 50 mu g/mL, the compound 12d had broad and the highest inhibitory activity with the 100% inhibition against the three tested strains, the same as norfloxacin which was used as the control.
引用
收藏
页码：555 / 560
页数：6
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