Synthesis and Antibacterial Evaluation of Thiouracil Derivatives Contain-ing 1,2,4-Triazolo[1,5-a]Pyrimidine

被引：1

作者：

Cui, Penglei ^{[1
]}

Zhang, Di ^{[2
]}

Guo, Xiumin ^{[1
]}

Ji, Shujing ^{[1
]}

Jiang, Qingmei ^{[1
]}

机构：

[1] Hebei Agr Univ, Coll Sci, Baoding 071001, Peoples R China

[2] Hebei Agr Univ, Coll Food Sci & Technol, Baoding 071001, Peoples R China

来源：

LETTERS IN ORGANIC CHEMISTRY | 2021年 / 18卷 / 07期

关键词：

Thiouracil; antibacterial activity; triazole; pyrimidine; synthesis; norfloxacin; SECA; DESIGN; INHIBITOR; ANALOGS;

D O I：

10.2174/1570178617999200826164227

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of new thiouracil compounds containing 1,2,4-triazolo[1,5-a]pyrimidine were designed and synthesized. The in vitro antibacterial activities of the new compounds against Bacillus amyloliquefaciens, Staphylococcus aureus and Bacillus subtilis were tested. The results showed that some of the new compounds had strong inhibitory activities against the tested bacteria. At the concentration of 50 mu g/mL, the compound 12d had broad and the highest inhibitory activity with the 100% inhibition against the three tested strains, the same as norfloxacin which was used as the control.

引用

页码：555 / 560

页数：6

共 50 条

[21] Synthesis of 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Antimicrobial activity, DNA Gyrase inhibition and molecular docking
Abd El-Aleam, Rehab H.
George, Riham F.
Hassan, Ghaneya S.
Abdel-Rahman, Hamdy M.
BIOORGANIC CHEMISTRY, 2020, 94
[22] Synthesis, Characterization, Antibacterial, Antifungal and Anticorrosion Activities of 1,2,4-Triazolo[1,5-a]quinazolinone
Ettahiri, Walid
Salim, Rajae
Adardour, Mohamed
Ech-chihbi, Elhachmia
Yunusa, Ismaeel
Alanazi, Mohammed M.
Lahmidi, Sanae
El Barnossi, Azeddin
Merzouki, Oussama
Housseini, Abdelilah Iraqi
Rais, Zakia
Baouid, Abdesselam
Taleb, Mustapha
MOLECULES, 2023, 28 (14):
[23] USE OF FORMAMIDE IN SYNTHESIS OF 1,2,4-TRIAZOLO[1,5-A]BENZIMIDAZOLES
KUZMENKO, VV
KUZMENKO, TA
SIMONOV, AM
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1987, (02): : 278 - 278
[24] Synthesis and Antitumor Activity of 1,2,4-Triazolo[1,5-a]quinazolines
Al-Salahi, R.
Marzouk, M.
Ashour, A. E.
Alswaidan, I.
ASIAN JOURNAL OF CHEMISTRY, 2014, 26 (07) : 2173 - 2176
[25] 1,2,4-TRIAZOLO[1,5]PYRIMIDINE DERIVATIVES ANNELATED BY CARBOCYCLES
DESENKO, SM
ESTRADA, H
ORLOV, VD
PONOMARYOV, OA
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1991, (01): : 105 - 108
[26] A convenient route to the 1,2,5-oxadiazole-substituted 1,2,4-triazolo[1,5-a]pyrimidine derivatives
Mikhail A. Prezent
Sergey V. Baranin
Chemistry of Heterocyclic Compounds, 2019, 55 : 1131 - 1134
[27] Synthesis and Biological Activity of Diheterocyclic 5,7-Dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Derivatives
Ma, Zhong-Hua
Liu, Zu-Ming
Chen, Qiong
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2008, 28 (11) : 1965 - 1970
[28] Synthesis of [1,2,4]triazolo[1,5-a]pyrimidine (microreview)
Maksym Fizer
Mikhailo Slivka
Chemistry of Heterocyclic Compounds, 2016, 52 : 155 - 157
[29] A convenient route to the 1,2,5-oxadiazole-substituted 1,2,4-triazolo[1,5-a]pyrimidine derivatives
Prezent, Mikhail A.
Baranin, Sergey, V
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (11) : 1131 - 1134
[30] NEW HERBICIDAL DERIVATIVES OF 1,2,4-TRIAZOLO[1,5A]PYRIMIDINE
KLESCHICK, WA
COSTALES, MJ
DUNBAR, JE
MEIKLE, RW
MONTE, WT
PEARSON, NR
SNIDER, SW
VINOGRADOFF, AP
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1987, 194 : 162 - AGRO

← 1 2 3 4 5 →