Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes

被引：93
|
作者：
Xie, Zhiyu [1 ,3 ]
Liu, Xigong [1 ]
Liu, Lei [1 ,2 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[2] Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
[3] Xuchang Univ, Coll Chem & Chem Engn, Xuchang 461000, Peoples R China
来源：
ORGANIC LETTERS | 2016年 / 18卷 / 12期
基金：
美国国家科学基金会;
关键词：
C-H BONDS; TRANSITION-METAL CATALYSIS; ALPHA-AMINO; TERTIARY-AMINES; MOLECULAR-OXYGEN; ASYMMETRIC ALKYNYLATION; VERSATILE APPROACH; ACID CATALYSIS; DUAL CATALYSIS; BRONSTED ACID;
D O I：
10.1021/acs.orglett.6b01328
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A copper-catalyzed enantioselective cross-coupling of a C-sp3-H moiety (N-aryl glycine ester) with a C-sp-H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural alpha-amino acids.
引用
收藏
页码：2982 / 2985
页数：4
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