Photocatalytic aerobic cross-coupling reaction of N-substituted anilines with N-aryl glycine esters: Synthesis of α-aryl α-amino esters

被引：22
|
作者：
Sun, Bin [1 ]
Deng, Jiacheng [2 ]
Li, Deyu [2 ]
Jin, Can [2 ]
Su, Weike [1 ,2 ]
机构：
[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 49期
基金：
中国国家自然科学基金;
关键词：
Cross dehydrogenative coupling; Photocatalysis; C-C bond formation; alpha-Aryla alpha-amino esters; Metal-free; VISIBLE-LIGHT PHOTOREDOX; CATALYZED OXIDATIVE CYANATION; TRANSITION-METAL; CARBONYL-COMPOUNDS; HYDROGEN-PEROXIDE; TERTIARY-AMINES; ACID CATALYSIS; ARYLATION; FUNCTIONALIZATION; DERIVATIVES;
D O I：
10.1016/j.tetlet.2018.10.067
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel photocatalytic cross dehydrogenative coupling reaction of N-aryl glycine esters with N-substituted anilines has been developed. The reaction proceeds effectively using methylene blue as a photocatalyst under visible light irradiation without any metal, chemical oxidant or additive. A variety of alpha-aryl alpha-amino derivatives were prepared in moderate to excellent yields with a high para-regioselectivity. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4364 / 4369
页数：6
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