A deletion in the N gene of SARS-CoV-2 may reduce test sensitivity for detection of SARS-CoV-2

被引：12

作者：

Wang, Huanyu ^{[1
,2
]}

Jean, Sophonie ^{[1
,2
]}

Wilson, Sarah A. ^{[4
]}

Lucyshyn, Jocelyn M. ^{[4
]}

McGrath, Sean ^{[4
]}

Wilson, Richard K. ^{[2
,4
]}

Magrini, Vincent ^{[2
,4
]}

Leber, Amy L. ^{[1
,2
,3
]}

机构：

[1] Ohio State Univ, Nationwide Childrens Hosp, Dept Pathol & Lab Med, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA

[4] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Steve & Cindy Rasmussen Inst Genom Med, Columbus, OH USA

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2022年 / 102卷 / 04期

关键词：

SARS-CoV-2; NAAT; mutation;

D O I：

10.1016/j.diagmicrobio.2021.115631

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

One SARS-CoV-2-positive sample demonstrated impaired detection of the N1 target by RT-PCR using US CDC primer/probe sets. A 3 nucleotide deletion was discovered that overlaps the forward primer binding site. This finding underscores the importance of continued SARS-CoV-2 mutation surveillance and assessment of the impact on diagnostic test performance. (C) 2021 Elsevier Inc. All rights reserved.

引用

页数：3

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