A deletion in the N gene of SARS-CoV-2 may reduce test sensitivity for detection of SARS-CoV-2

被引：12
|
作者：
Wang, Huanyu [1 ,2 ]
Jean, Sophonie [1 ,2 ]
Wilson, Sarah A. [4 ]
Lucyshyn, Jocelyn M. [4 ]
McGrath, Sean [4 ]
Wilson, Richard K. [2 ,4 ]
Magrini, Vincent [2 ,4 ]
Leber, Amy L. [1 ,2 ,3 ]
机构：
[1] Ohio State Univ, Nationwide Childrens Hosp, Dept Pathol & Lab Med, Columbus, OH 43210 USA
[2] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Pediat, Columbus, OH 43210 USA
[4] Nationwide Childrens Hosp, Abigail Wexner Res Inst, Steve & Cindy Rasmussen Inst Genom Med, Columbus, OH USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2022年 / 102卷 / 04期
关键词：
SARS-CoV-2; NAAT; mutation;
D O I：
10.1016/j.diagmicrobio.2021.115631
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
One SARS-CoV-2-positive sample demonstrated impaired detection of the N1 target by RT-PCR using US CDC primer/probe sets. A 3 nucleotide deletion was discovered that overlaps the forward primer binding site. This finding underscores the importance of continued SARS-CoV-2 mutation surveillance and assessment of the impact on diagnostic test performance. (C) 2021 Elsevier Inc. All rights reserved.
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页数：3
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