Antiviral flavonoids from the root bark of Morus alba L.

被引：243
|
作者：
Du, J
He, ZD
Jiang, RW
Ye, WC
Xu, HX
But, PPH [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Biol & Chem, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China
来源：
PHYTOCHEMISTRY | 2003年 / 62卷 / 08期
关键词：
Morus alba; Moraceae; moralbanone; leachianone; mulberroside; flavonoid; antiviral; herpes;
D O I：
10.1016/S0031-9422(02)00753-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC50= 1.6 mug/ml), whereas mulberroside C showed weak activity (IC50=75.4 mug/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1235 / 1238
页数：4
相关论文
共 50 条
  • [41] FLAVONOIDS OF Morus alba
    Liu, C. M.
    Yeh, H. C.
    Wu, H. M.
    Li, W. J.
    Li, H. T.
    Chuang, C. H.
    Chen, C. Y.
    CHEMISTRY OF NATURAL COMPOUNDS, 2021, 57 (06) : 1119 - 1121
  • [42] Prenylated flavonoids and total extracts from Morus nigra L. root bark inhibit in vitro growth of plant pathogenic fungi
    Simonetti, G.
    Brasili, E.
    D'Auria, F. D.
    Corpolongo, S.
    Ferrari, F.
    Pasqua, G.
    Valletta, A.
    PLANT BIOSYSTEMS, 2017, 151 (05): : 783 - 787
  • [43] PREPARATIVE ISOLATION OF FLAVONOIDS FROM MULBERRY (MORUS ALBA L.) LEAVES BY MACROPOROUS RESIN ADSORPTION
    Jia, Dongdong
    Li, Shufen
    Gu, Zhipeng
    JOURNAL OF FOOD PROCESS ENGINEERING, 2011, 34 (04) : 1319 - 1337
  • [44] alpha-Glucosidase inhibitors and antioxidants from root bark of Morus alba
    Liu, Bing-rui
    Yan, Tie-ping
    Xiao, Jian
    Wang, Xiao-ling
    CHINESE HERBAL MEDICINES, 2018, 10 (03) : 331 - 335
  • [45] Evaluation of anti-hyperuricemic and nephroprotective activities and discovery of new XOD inhibitors of Morus alba L. root bark
    Wang, Yan-Ao
    Guo, Xu
    Zhang, Meng-Qi
    Sun, Shu-Tao
    Ren, Qi-Dong
    Wang, Mu-Xuan
    Wang, Li-Na
    Farag, Mohamed A.
    Sun, Jin-Yue
    Liu, Chao
    Chen, Ying-Ying
    JOURNAL OF ETHNOPHARMACOLOGY, 2025, 343
  • [46] Antioxidative flavonoids from the leaves of Morus alba
    Kim, SY
    Gao, JJ
    Lee, WC
    Ryu, KS
    Lee, KR
    Kim, YC
    ARCHIVES OF PHARMACAL RESEARCH, 1999, 22 (01) : 81 - 85
  • [47] Cytotoxic prenylated flavonoids from Morus alba
    Nguyen Tien Dat
    Phung Thi Xuan Binh
    Le Thi Phuong Quynh
    Chau Van Minh
    Hoang Thanh Huong
    Lee, Jung Joon
    FITOTERAPIA, 2010, 81 (08) : 1224 - 1227
  • [48] Isolation and structure elucidation of a new linoleiyl glycoside and flavones from the stem bark of Morus alba L.
    Ali, Abuzer
    Ali, Mohammed
    FUTURE JOURNAL OF PHARMACEUTICAL SCIENCES, 2016, 2 (02) : 82 - 86
  • [49] Study on Ultrasonic-Microwave Synergistic Extraction of Total Flavonoids from Morus alba L. Leaves
    LI Li*
    Medicinal Plant, 2010, (06) : 46 - 48
  • [50] Isolation and identification of Isoquercitrin from extracts obtained from leaves of Morus alba (L.) and Morus nigra (L.)
    Muntean, D
    Csedó, C
    PROCEEDINGS OF THE INTERNATIONAL CONFERENCE ON MEDICINAL AND AROMATIC PLANTS, PT II: (FOLLOW UP OF ACTA HORTICULTURAE 576), 2003, (597): : 105 - 114
12345