Antiviral flavonoids from the root bark of Morus alba L.

被引：243
|
作者：
Du, J
He, ZD
Jiang, RW
Ye, WC
Xu, HX
But, PPH [1 ]
机构：
[1] Chinese Univ Hong Kong, Dept Biol & Chem, Shatin, Hong Kong, Peoples R China
[2] Chinese Univ Hong Kong, Inst Chinese Med, Shatin, Hong Kong, Peoples R China
[3] China Pharmaceut Univ, Dept Phytochem, Nanjing 210009, Peoples R China
来源：
PHYTOCHEMISTRY | 2003年 / 62卷 / 08期
关键词：
Morus alba; Moraceae; moralbanone; leachianone; mulberroside; flavonoid; antiviral; herpes;
D O I：
10.1016/S0031-9422(02)00753-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A prenylated flavonoid, moralbanone, along with seven known compounds kuwanon S, mulberroside C, cyclomorusin, eudraflavone B hydroperoxide, oxydihydromorusin, leachianone G and alpha-acetyl-amyrin were isolated from the root bark of Morus alba L. Leachianone G showed potent antiviral activity (IC50= 1.6 mug/ml), whereas mulberroside C showed weak activity (IC50=75.4 mug/ml) against herpes simplex type 1 virus (HSV-1). Their structures were elucidated by spectroscopic methods. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1235 / 1238
页数：4
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