Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

被引：3
|
作者：
Zhang, Yuanyuan [2 ]
Chen, Guangmin [1 ]
Weng, Yabiao [3 ]
Li, Renliang [3 ]
Wang, Yuliang [1 ,2 ]
Wang, Yuzhong [1 ,2 ]
机构：
[1] Sichuan Univ, Dept Chem, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Dept Chem Engn, Chengdu 610065, Peoples R China
[3] S China Agr Univ, Dept Vet Med, Guangzhou 510642, Guangdong, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 06期
基金：
美国国家科学基金会;
关键词：
3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone; Derivatives; Synthesis; Anticoccidial activity; Eimeria tenella; EIMERIA; RESISTANCE; TENELLA;
D O I：
10.2174/157018010791306498
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chicken's diet with a dose of 18 mg/Kg.
引用
收藏
页码：471 / 475
页数：5
相关论文
共 50 条
  • [41] Synthesis and Antimicrobial Evaluation of (1-(2-(Benzyloxy)-2-oxoethyl)-1H-1,2,3-triazol-4-yl)methyl Benzoate Analogues
    Kaushik, C. P.
    Pahwa, Ashima
    Kumar, Devinder
    Kumar, Ashwani
    Singh, Dharmendra
    Kumar, Krishan
    Luxmi, Raj
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 55 (07) : 1720 - 1728
  • [42] 3-(2-Methoxynaphthalen-1-yl)-2-benzofuran-1(3H)-one
    Silambarasan, V.
    Sundaramoorthy, S.
    Sivasakthikumaran, R.
    Mohanakrishnan, A. K.
    Velmurugan, D.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1973 - U2416
  • [43] Synthesis, computational studies, tyrosinase inhibitory kinetics and antimelanogenic activity of hydroxy substituted 2-[(4-acetylphenyl)amino]-2-oxoethyl derivatives
    Rafiq, Muhammad
    Nazir, Yasir
    Ashraf, Zaman
    Rafique, Hummera
    Afzal, Samina
    Mumtaz, Amara
    Hassan, Mubashir
    Ali, Anser
    Afzal, Khurram
    Yousuf, Muhammad Rizwan
    Saleem, Muhammad
    Kotwica-Mojzych, Katarzyna
    Mojzych, Mariusz
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2019, 34 (01) : 1562 - 1572
  • [44] N-(2-(1H-Indol-3-yl)ethyl)-2-(6-methoxynaphthalen-2-yl)propanamide
    Manolov, Stanimir
    Ivanov, Iliyan
    Bojilov, Dimitar
    MOLBANK, 2021, 2021 (01) : 1 - 4
  • [45] Crystal structure of (E)-N-{2-[2-(2-chlorobenzylidene)hydrazin-1-yl]-2-oxoethyl}-4-methylbenzamide monohydrate
    Purandara, H.
    Foro, Sabine
    Gowda, B. Thimme
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2015, 71 : 795 - +
  • [46] 2-[2-(3-Chlorophenyl)-2-oxoethyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
    Khalid, Zunera
    Siddiqui, Hamid Latif
    Ahmad, Matloob
    Bukhari, Iftikhar Hussain
    Parvez, Masood
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O617 - U5022
  • [47] 2-(4-Chlorophenyl)-2-oxoethyl 2,4-difluorobenzoate
    Fun, Hoong-Kun
    Arshad, Suhana
    Garudachari, B.
    Isloor, Arun M.
    Satyanarayan, M. N.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1599 - U2116
  • [48] 2-[2-(3-Methoxyphenyl)-2-oxoethyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
    Gul, Salman
    Siddiqui, Hamid Latif
    Ahmad, Matloob
    Azam, Muhammad
    Parvez, Masood
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : 0618 - U5032
  • [49] 2-(2,4-Dichlorophenyl)-2-oxoethyl 4-methoxybenzoate
    Fun, Hoong-Kun
    Chia, Tze Shyang
    Shenvi, Seema
    Isloor, Arun M.
    Garudachari, B.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O3379 - U298
  • [50] 2-[2-(2-Bromophenyl)-2-oxoethyl]-1 lambda(6),2-benzothiazole-1,1,3-trione
    Sattar, Nazia
    Siddiqui, Hamid Latif
    Siddiqui, Waseeq Ahmad
    Akram, Muhammad
    Parvez, Masood
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O1889 - +
12345