Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

被引：3
|
作者：
Zhang, Yuanyuan [2 ]
Chen, Guangmin [1 ]
Weng, Yabiao [3 ]
Li, Renliang [3 ]
Wang, Yuliang [1 ,2 ]
Wang, Yuzhong [1 ,2 ]
机构：
[1] Sichuan Univ, Dept Chem, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Dept Chem Engn, Chengdu 610065, Peoples R China
[3] S China Agr Univ, Dept Vet Med, Guangzhou 510642, Guangdong, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 06期
基金：
美国国家科学基金会;
关键词：
3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone; Derivatives; Synthesis; Anticoccidial activity; Eimeria tenella; EIMERIA; RESISTANCE; TENELLA;
D O I：
10.2174/157018010791306498
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chicken's diet with a dose of 18 mg/Kg.
引用
收藏
页码：471 / 475
页数：5
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