Synthesis and Anticoccidial Activity of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) Quinazolinone Derivatives

被引：3
|
作者：
Zhang, Yuanyuan [2 ]
Chen, Guangmin [1 ]
Weng, Yabiao [3 ]
Li, Renliang [3 ]
Wang, Yuliang [1 ,2 ]
Wang, Yuzhong [1 ,2 ]
机构：
[1] Sichuan Univ, Dept Chem, Chengdu 610064, Peoples R China
[2] Sichuan Univ, Dept Chem Engn, Chengdu 610065, Peoples R China
[3] S China Agr Univ, Dept Vet Med, Guangzhou 510642, Guangdong, Peoples R China
来源：
LETTERS IN DRUG DESIGN & DISCOVERY | 2010年 / 7卷 / 06期
基金：
美国国家科学基金会;
关键词：
3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone; Derivatives; Synthesis; Anticoccidial activity; Eimeria tenella; EIMERIA; RESISTANCE; TENELLA;
D O I：
10.2174/157018010791306498
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of 3-(2-(1-methoxynaphthalen-2-yl)-2-oxoethyl) quinazolinone derivatives (8a-k) were designed and synthesized. Their anticoccidial activities were evaluated against Eimeria tenella in vivo. The results indicated that compounds 8a, 8b and 8e exhibited anticoccidial activity against Eimeria tenella in the chicken's diet with a dose of 18 mg/Kg.
引用
收藏
页码：471 / 475
页数：5
相关论文
共 50 条
  • [1] Design, synthesis and anticoccidial activity of a series of 3-(2-(2-methoxyphenyl)-2-oxoethyl) quinazolinone derivatives
    Ye, Changwen
    You, Junhui
    Li, XiaoFeng
    You, Rong
    Weng, Yabiao
    Li, Jun
    Wang, Yuliang
    PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 2010, 97 (03) : 194 - 198
  • [2] Synthesis and anticoccidial activity of 3-(2-(benzofuran)-2-yl)-2-oxoethylquinazolinone derivatives
    Xin, Ying
    Xie, Min
    Zou, Li-Juan
    Nie, Kui
    Wang, Yu-Liang
    JOURNAL OF CHEMICAL RESEARCH, 2012, (03) : 127 - 130
  • [3] Synthesis of 2-(2,5-Dihydrofuran-3-yl)-2-oxoethyl carboxylates
    Avetisyan, K. S.
    Galstyan, L. Kh.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2013, 49 (06) : 936 - 939
  • [4] Synthesis of 2-(2,5-Dihydrofuran-3-yl)-2-oxoethyl carboxylates
    K. S. Avetisyan
    L. Kh. Galstyan
    Russian Journal of Organic Chemistry, 2013, 49 : 936 - 939
  • [5] Benzyl {2-[(2-(1H-Benzo[d][1,2,3]triazol-1-yl)-2-oxoethyl)amino]-2-oxoethyl} carbamate
    Kucukbay, Hasan
    Bugday, Nesrin
    MOLBANK, 2014, (03)
  • [6] 2-(4-Chlorophenyl)-2-oxoethyl 3-(trifluoromethyl)benzoate
    Fun, Hoong-Kun
    Loh, Wan-Sin
    Garudachari, B.
    Isloor, Arun M.
    Satyanarayan, M. N.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1597 - U2093
  • [7] 2-(4-Fluorophenyl)-2-oxoethyl 3-(trifluoromethyl)benzoate
    Fun, Hoong-Kun
    Arshad, Suhana
    Garudachari, B.
    Isloor, A. M.
    Shivananda, Kammasandra N.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O2836 - +
  • [8] Synthesis of 3-acetonyl- and 3-(2-oxoethyl)glutarates
    Amat, M
    Bassas, O
    Cantó, M
    Llor, N
    Santos, MMM
    Bosch, J
    TETRAHEDRON, 2005, 61 (32) : 7693 - 7702
  • [9] Synthesis and Anti Convulsant Activity of "N'-{4-[2-(1h-Benzimidazol-2-Yl)-2-Oxoethyl] Phenyl}-2-Hydroxyacetohydrazide and Its Derivatives
    Bhor, Rohit Jaysing
    Sable, Komal Sakharam
    Bhosale, Mayur Shivaji
    Dighe, Santosh Bhausaheb
    ADVANCES IN PHARMACOLOGY AND PHARMACY, 2023, 11 (01) : 46 - 56
  • [10] Crystal structure of 2-(4-chlorophen-yl)-2-oxoethyl 3-bromobenzoate
    Khan, Imtiaz
    Ibrar, Aliya
    Hameed, Shahid
    White, Jonathan M.
    Simpson, Jim
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2014, 70 : 301 - +
12345