Synthesis of 2,3-disubstituted indole on solid phase by the Fischer indole synthesis

被引：27
|
作者：
Mun, HS
Ham, WH
Jeong, JH [1 ]
机构：
[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
[2] Sungkyunkwan Univ, Suwon 440746, South Korea
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 2005年 / 7卷 / 01期
关键词：
D O I：
10.1021/cc049922e
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon-carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.
引用
收藏
页码：130 / 135
页数：6
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