Synthesis of 2,3-disubstituted indole on solid phase by the Fischer indole synthesis

被引：27

作者：

Mun, HS

Ham, WH

Jeong, JH ^{[1
]}

机构：

[1] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[2] Sungkyunkwan Univ, Suwon 440746, South Korea

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 2005年 / 7卷 / 01期

关键词：

D O I：

10.1021/cc049922e

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

2,3-Disubstituted indoles were synthesized by solid-phase reaction using the Fischer indole synthesis. A "traceless" silicon linker was employed with the silicon-carbon bonding being cleaved with TFA. An oxygen atom was placed into the middle of the spacer/linker so as to enhance solid-phase synthesis by better solvation.

引用

页码：130 / 135

页数：6

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