In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(η5-cyclopentadienyl)difluorotitanium(IV)

被引：11
|
作者：
Koleros, Elias [1 ]
Stamatatos, Theocharis C. [1 ]
Psycharis, Vassilis [2 ]
Raptopoulou, Catherine P. [2 ]
Perlepes, Spyros P. [1 ]
Klouras, Nikolaos [1 ]
机构：
[1] Univ Patras, Dept Chem, Patras 26504, Greece
[2] NCSR Demokritos, Inst Mat Sci, Attikis 15310, Greece
来源：
BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2010年 / 2010卷
关键词：
TUMOR-INHIBITION; CLINICAL-TRIAL; DICHLORIDE; CANCER; METALLOCENES; DERIVATIVES;
D O I：
10.1155/2010/914580
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The 1 : 2 reaction of [Ti(eta(5)-C5H5)(2)Cl-2] and AgF in CHCl3/H2O yielded the fluoro analog [Ti(eta(5)-C5H5)(2)F-2] (1) in almost quantitative yield (C5H5 is the cyclopentadienyl group). The coordination about the Ti-IV atom formed by two fluoro ligands and the centroids of the cyclopentadienyl rings is distorted tetrahedral. The compound crystallizes in the orthorhombic space group C2cm. The lattice constants are a = 5.9055(4), b = 10.3021(5), c = 14.2619(9) angstrom, and alpha = beta = gamma = 90 degrees. The complex has been characterized by elemental analyses and spectroscopic (IR, H-1 NMR) data. A structural comparison of the four members of the [Ti(eta(5)-C5H5)(2)X-2] family of complexes (X = F, Cl, Br, I) is attempted.
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页数：6
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