In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(η5-cyclopentadienyl)difluorotitanium(IV)

被引：11

作者：

Koleros, Elias ^{[1
]}

Stamatatos, Theocharis C. ^{[1
]}

Psycharis, Vassilis ^{[2
]}

Raptopoulou, Catherine P. ^{[2
]}

Perlepes, Spyros P. ^{[1
]}

Klouras, Nikolaos ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Patras 26504, Greece

[2] NCSR Demokritos, Inst Mat Sci, Attikis 15310, Greece

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2010年 / 2010卷

关键词：

TUMOR-INHIBITION; CLINICAL-TRIAL; DICHLORIDE; CANCER; METALLOCENES; DERIVATIVES;

D O I：

10.1155/2010/914580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1 : 2 reaction of [Ti(eta(5)-C5H5)(2)Cl-2] and AgF in CHCl3/H2O yielded the fluoro analog [Ti(eta(5)-C5H5)(2)F-2] (1) in almost quantitative yield (C5H5 is the cyclopentadienyl group). The coordination about the Ti-IV atom formed by two fluoro ligands and the centroids of the cyclopentadienyl rings is distorted tetrahedral. The compound crystallizes in the orthorhombic space group C2cm. The lattice constants are a = 5.9055(4), b = 10.3021(5), c = 14.2619(9) angstrom, and alpha = beta = gamma = 90 degrees. The complex has been characterized by elemental analyses and spectroscopic (IR, H-1 NMR) data. A structural comparison of the four members of the [Ti(eta(5)-C5H5)(2)X-2] family of complexes (X = F, Cl, Br, I) is attempted.

引用

页数：6

共 50 条

[11] The synthesis, spectroscopic, X-ray characterization and in vitro cytotoxic testing results of activity of five new trans-platinum(IV) complexes with functionalized pyridines
Rakic, Gordana M.
Grguric-Sipka, Sanja
Kaluderovic, Goran N.
Bette, Martin
Filipovic, Lana
Arandelovic, Sandra
Radulovic, Sinisa
Tesic, Zivoslav Lj
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 : 214 - 219
[12] Synthesis, spectroscopic and X-ray structure characterisation of bis(tetramethylammonium), bis(tetraethylammonium) and bis(tetrapropylammonium) tetrathiotungstates
Poisot, Martha
Naether, Christian
Bensch, Wolfgang
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2006, 61 (09): : 1061 - 1066
[13] Triorganotin(IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities
Khan, Naqeebullah
Farina, Yang
Mun, Lo Kong
Rajab, Nor Fadilah
Awang, Normah
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2014, 763 : 26 - 33
[14] THE SYNTHESIS AND STRUCTURE OF SILICA-SUPPORTED BIS(H5-CYCLOPENTADIENYL)DICHLOROTITANIUM(IV) COMPLEXES
REISSOVA, A
BASTL, Z
CAPKA, M
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1986, 51 (07) : 1430 - 1438
[15] Bis-indenyl molybdenum(IV) halide complexes:: synthesis and X-ray studies
Drew, MGB
Félix, V
Romao, CC
Royo, B
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 2002, (04): : 584 - 590
[16] Synthesis and X-ray structure analysis of cytotoxic 2-picolylamino-type HfIV-bis-chelated complexes
Zhao, Tiankun
Zhang, Qi
Zhao, Jialiu
Mei, Dongyu
Ma, Jing
Correia, Isabel
Yang, Zhongduo
Kim, Sa-Hyun
Huhn, Thomas
DALTON TRANSACTIONS, 2025,
[17] Synthesis, spectroscopic and X-ray single-crystal structure study of bis(2-methoxy-ethanolato)-bis(8-quinolinato)titanium(IV)
Mirzaee, M
Amini, MM
APPLIED ORGANOMETALLIC CHEMISTRY, 2005, 19 (03) : 339 - 342
[18] Synthesis, spectroscopic characterization and X-ray structure analyses of two uranyl complexes
Hazra, Dipak K.
Dinda, Subhajit
Helliwell, Madeleine
Bhattacharyya, Ramgopal
Mukherjee, Monika
ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 2009, 224 (11): : 544 - 550
[19] Cytotoxic heteroleptic heptacoordinate salan zirconium(IV)-bis-chelates - synthesis, aqueous stability and X-ray structure analysis
Schneider, Fabian
Zhao, Tiankun
Huhn, Thomas
CHEMICAL COMMUNICATIONS, 2016, 52 (66) : 10151 - 10154
[20] AN X-RAY PHOTOELECTRON SPECTROSCOPIC STUDY OF SOME BIS(DIAMINE) COPPER(II) COMPLEXES
ROE, SP
HILL, JO
LIESEGANG, J
JOURNAL OF ELECTRON SPECTROSCOPY AND RELATED PHENOMENA, 1988, 46 (04) : 315 - 324

← 1 2 3 4 5 →