In Search for Titanocene Complexes with Improved Cytotoxic Activity: Synthesis, X-Ray Structure, and Spectroscopic Study of Bis(η5-cyclopentadienyl)difluorotitanium(IV)

被引：11

作者：

Koleros, Elias ^{[1
]}

Stamatatos, Theocharis C. ^{[1
]}

Psycharis, Vassilis ^{[2
]}

Raptopoulou, Catherine P. ^{[2
]}

Perlepes, Spyros P. ^{[1
]}

Klouras, Nikolaos ^{[1
]}

机构：

[1] Univ Patras, Dept Chem, Patras 26504, Greece

[2] NCSR Demokritos, Inst Mat Sci, Attikis 15310, Greece

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2010年 / 2010卷

关键词：

TUMOR-INHIBITION; CLINICAL-TRIAL; DICHLORIDE; CANCER; METALLOCENES; DERIVATIVES;

D O I：

10.1155/2010/914580

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The 1 : 2 reaction of [Ti(eta(5)-C5H5)(2)Cl-2] and AgF in CHCl3/H2O yielded the fluoro analog [Ti(eta(5)-C5H5)(2)F-2] (1) in almost quantitative yield (C5H5 is the cyclopentadienyl group). The coordination about the Ti-IV atom formed by two fluoro ligands and the centroids of the cyclopentadienyl rings is distorted tetrahedral. The compound crystallizes in the orthorhombic space group C2cm. The lattice constants are a = 5.9055(4), b = 10.3021(5), c = 14.2619(9) angstrom, and alpha = beta = gamma = 90 degrees. The complex has been characterized by elemental analyses and spectroscopic (IR, H-1 NMR) data. A structural comparison of the four members of the [Ti(eta(5)-C5H5)(2)X-2] family of complexes (X = F, Cl, Br, I) is attempted.

引用

页数：6

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