Anti-NDV activity of baicalin from a traditional Chinese medicine in vitro

被引：26

作者：

Jia, Yan ^{[1
]}

Xu, Ruiguang ^{[2
]}

Hu, Yanchun ^{[2
]}

Zhu, Tianlong ^{[1
]}

Ma, Tingting ^{[2
]}

Wu, Haihong ^{[1
]}

Hu, Liwen ^{[2
]}

机构：

[1] Jiaxing Vocat Tech Coll, Agr & Environm Branch, Jiaxing 314036, Zhejiang, Peoples R China

[2] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Wenjiang 611130, Sichuan Provinc, Peoples R China

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 05期

关键词：

apoptosis; Baicalin; newcastle disease virus (NDV); Virus inhibitory rate; NEWCASTLE-DISEASE VIRUS; ACID BINDING-SITE; ANTIVIRAL ACTIVITY; HEMAGGLUTININ-NEURAMINIDASE; CELLULAR INFECTIVITY; HERBAL MEDICINE; POLYSACCHARIDE; APOPTOSIS; THERAPY; VACCINE;

D O I：

10.1292/jvms.15-0572

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The purpose of this study was to investigate the anti-Newcastle disease virus (NDV) activities of baicalin from Scutellaria baicalensis, a Traditional Chinese Medicine in vitro. Chicken embryo fibroblasts (CEFs) were infected with NDV, and quantitative analysis of apoptotic cells was performed using flow cytometry. Cytotoxicity and anti-viral activities of baicalin were studied using the MTT method. The results showed that the maximal safe concentrations of baicalin to CEFs was 1 x 2(-2) mg/ml. Baicalin could directly kill NDV, inhibit the infectivity of NDV to CEF and block intracellular NDV. It inhibited the apoptosis of NDV-infected CEFs and suppressed the spread of NDV. These results indicate that baicalin has strong anti-NDV activity and has the potential for use as components of an antiviral drug.

引用

页码：819 / 824

页数：6

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