Anti-NDV activity of baicalin from a traditional Chinese medicine in vitro

被引：26
|
作者：
Jia, Yan [1 ]
Xu, Ruiguang [2 ]
Hu, Yanchun [2 ]
Zhu, Tianlong [1 ]
Ma, Tingting [2 ]
Wu, Haihong [1 ]
Hu, Liwen [2 ]
机构：
[1] Jiaxing Vocat Tech Coll, Agr & Environm Branch, Jiaxing 314036, Zhejiang, Peoples R China
[2] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Wenjiang 611130, Sichuan Provinc, Peoples R China
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 05期
关键词：
apoptosis; Baicalin; newcastle disease virus (NDV); Virus inhibitory rate; NEWCASTLE-DISEASE VIRUS; ACID BINDING-SITE; ANTIVIRAL ACTIVITY; HEMAGGLUTININ-NEURAMINIDASE; CELLULAR INFECTIVITY; HERBAL MEDICINE; POLYSACCHARIDE; APOPTOSIS; THERAPY; VACCINE;
D O I：
10.1292/jvms.15-0572
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The purpose of this study was to investigate the anti-Newcastle disease virus (NDV) activities of baicalin from Scutellaria baicalensis, a Traditional Chinese Medicine in vitro. Chicken embryo fibroblasts (CEFs) were infected with NDV, and quantitative analysis of apoptotic cells was performed using flow cytometry. Cytotoxicity and anti-viral activities of baicalin were studied using the MTT method. The results showed that the maximal safe concentrations of baicalin to CEFs was 1 x 2(-2) mg/ml. Baicalin could directly kill NDV, inhibit the infectivity of NDV to CEF and block intracellular NDV. It inhibited the apoptosis of NDV-infected CEFs and suppressed the spread of NDV. These results indicate that baicalin has strong anti-NDV activity and has the potential for use as components of an antiviral drug.
引用
收藏
页码：819 / 824
页数：6
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