Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes

被引：24
|
作者：
Fei, Bao-Li [1 ,2 ]
Li, Wen [1 ]
Xu, Wu-Shuang [1 ]
Long, Jian-Ying [3 ]
Liu, Qing-Bo [3 ]
Sun, Wei-Yin [2 ]
Anson, Christopher E. [4 ]
Powell, Annie K. [4 ]
机构：
[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China
[2] Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China
[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Jiangsu, Peoples R China
[4] Karlsruhe Inst Technol, Inst Inorgan Chem, D-76131 Karlsruhe, Germany
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2013年 / 34期
关键词：
Cytotoxicity; DNA binding; Copper; Structure elucidation; Chirality; CU-II; NI-II; LIGAND; CU(II); CLEAVAGE; ZN(II); ANTIOXIDANT; NI(II);
D O I：
10.1002/ejic.201300685
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two chiral copper-(II) complexes [Cu(L)(2)Cl]Cl (1) and [Cu(L)(2)Br]Br (2) [L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu-II ions in 1 and 2 can be described as an intermediate between squarepyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA. through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential.
引用
收藏
页码：5919 / 5927
页数：9
相关论文
共 50 条
  • [41] Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand
    Subbaiyan Sathiyaraj
    Krishnan Sampath
    Ray J. Butcher
    Chinnasamy Jayabalakrishnan
    Transition Metal Chemistry, 2013, 38 : 291 - 298
  • [42] Synthesis, DNA binding, antioxidant and cytotoxic activities of ruthenium(II) complexes of a Schiff base ligand
    Sathiyaraj, Subbaiyan
    Sampath, Krishnan
    Butcher, Ray J.
    Jayabalakrishnan, Chinnasamy
    TRANSITION METAL CHEMISTRY, 2013, 38 (03) : 291 - 298
  • [43] Synthesis, Crystal Structures and Antibacterial Activities of Two Complexes of Copper Assembled by Triazole Pesticides Ligands
    Hu Chun-Yan
    Nie Xu-Liang
    Xiong Hui
    Huang Chang-Gan
    CHINESE JOURNAL OF INORGANIC CHEMISTRY, 2014, 30 (03) : 621 - 626
  • [44] Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin
    Tan, Mingxiong
    Zhu, Jinchan
    Pan, Yingming
    Chen, Zhenfeng
    Liang, Hong
    Liu, Huagang
    Wang, Hengshan
    BIOINORGANIC CHEMISTRY AND APPLICATIONS, 2009, 2009
  • [45] Synthesis, structure, and DNA binding studies of copper(II) complexes of terpyridine derivatives
    Uma, V
    Vaidyanathan, VG
    Nair, BU
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2005, 78 (05) : 845 - 850
  • [46] Synthesis, Crystal Structure, and Biological Activities of Two Chiral Mononuclear Mn(III) Complexes
    Wang, Bi-Wei
    Jiang, Lin
    Shu, Si-Sheng
    Li, Bo-Wen
    Dong, Zhang
    Gu, Wen
    Liu, Xin
    Tian, Jin-Lei
    CHIRALITY, 2015, 27 (02) : 142 - 150
  • [47] Antibacterial, DNA interaction and cytotoxic activities of pendant-armed polyamine macrocyclic dinuclear nickel(II) and copper(II) complexes
    Arthi, P.
    Haleel, A.
    Srinivasan, P.
    Prabhu, D.
    Arulvasu, C.
    Rahiman, A. Kalilur
    SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2014, 129 : 400 - 414
  • [48] Synthesis, crystal structure, cytotoxicity study, DNA/protein binding and molecular docking of dinuclear copper(II) complexes
    Bhunia, Apurba
    Mistri, Soumen
    Manne, Rajesh Kumar
    Santra, Manas Kumar
    Manna, Subal Chandra
    INORGANICA CHIMICA ACTA, 2019, 491 : 25 - 33
  • [49] Synthesis and crystal structure of two new nickel (II) and copper (II) tetraaza complexes
    He, Yi
    Kou, Hui-Zhong
    Zhou, Bei-Chuan
    Wang, Ru-Ji
    Li, Ya-Dong
    Wang, Hong-Gen
    Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities, 2002, 23 (11):
  • [50] Synthesis and crystal structure of two new nickel(II) and copper(II) tetraaza complexes
    He, Y
    Kou, HZ
    Zhou, BC
    Wang, RJ
    Li, YD
    Wang, HG
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2002, 23 (11): : 2017 - 2020
12345