Synthesis, Crystal Structure, DNA Binding, Antibacterial, and Cytotoxic Activities of Two Chiral Copper(II) Complexes

被引：24

作者：

Fei, Bao-Li ^{[1
,2
]}

Li, Wen ^{[1
]}

Xu, Wu-Shuang ^{[1
]}

Long, Jian-Ying ^{[3
]}

Liu, Qing-Bo ^{[3
]}

Sun, Wei-Yin ^{[2
]}

Anson, Christopher E. ^{[4
]}

Powell, Annie K. ^{[4
]}

机构：

[1] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Jiangsu, Peoples R China

[2] Nanjing Univ, Inst Coordinat Chem, State Key Lab Coordinat Chem, Nanjing 210093, Jiangsu, Peoples R China

[3] Nanjing Forestry Univ, Coll Sci, Nanjing 210037, Jiangsu, Peoples R China

[4] Karlsruhe Inst Technol, Inst Inorgan Chem, D-76131 Karlsruhe, Germany

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2013年 / 34期

关键词：

Cytotoxicity; DNA binding; Copper; Structure elucidation; Chirality; CU-II; NI-II; LIGAND; CU(II); CLEAVAGE; ZN(II); ANTIOXIDANT; NI(II);

D O I：

10.1002/ejic.201300685

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two chiral copper-(II) complexes [Cu(L)(2)Cl]Cl (1) and [Cu(L)(2)Br]Br (2) [L = N-[(pyridin-2-ylmethylene)imino]dehydroabietylamine} have been synthesized and fully characterized. The coordination geometry of the Cu-II ions in 1 and 2 can be described as an intermediate between squarepyramidal and trigonal-bipyramidal. DNA binding studies suggest that the complexes interact with salmon-sperm DNA. through intercalation, and 2 exhibits a higher binding affinity. The new complexes were screened for their antibacterial and cytotoxic ability. They have similar cytotoxic activity and they represent the first rosin-derivative-based simple Schiff base complexes with strong anticancer potential.

引用

页码：5919 / 5927

页数：9

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