Process Development of Selectively Benzoylated and Fluorinated Glycosyl Donors

被引：14

作者：

Weibeith, Franz J. ^{[1
]}

Gill, Harpal S. ^{[1
]}

Jiang, Ying ^{[1
]}

Lee, George E. ^{[1
]}

Lienard, Philippe ^{[1
]}

Pemberton, Clive ^{[1
]}

Powers, Matthew R. ^{[1
]}

Subotkowski, Witold ^{[1
]}

Tomasik, Witold ^{[1
]}

Vanasse, Benoit J. ^{[1
]}

Yu, Yong ^{[1
]}

机构：

[1] Sanofi Aventis US, Chem Dev, Bridgewater, NJ 08807 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2010年 / 14卷 / 03期

关键词：

DERIVATIVES; GLUCOSE; ALPHA; TRIFLUORIDE; MECHANISM; GALACTOSE;

D O I：

10.1021/op100053k

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Route selection, process development and large-scale preparation of selectively benzoylated and fluorinated D-glucopyranoses, required as glycosyl donors for the synthesis of the SGLT inhibitor SAR7226, are discussed.

引用

页码：623 / 631

页数：9

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