Lack of carcinogenicity of thiamphenicol in F344 rats

被引：10

作者：

Kitamura, T ^{[1
]}

Ando, J ^{[1
]}

Ishihara, R ^{[1
]}

Takano, S ^{[1
]}

Iijima, T ^{[1
]}

Nishimura, S ^{[1
]}

Yoshida, M ^{[1
]}

Takahashi, M ^{[1
]}

Maekawa, A ^{[1
]}

机构：

[1] Sasaki Inst, Dept Pathol, Chiyoda Ku, Tokyo 101, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1997年 / 35卷 / 10-11期

关键词：

D O I：

10.1016/S0278-6915(97)00114-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The carcinogenicity of thiamphenicol (TAP), an antibiotic drug, was examined in Fischer 344 rats of both sexes. TAP was given ad lib. in drinking water at levels of 0 (control), 125 or 250 ppm to groups of 50 male and 50 female rats for 2 yr. The treatment did not affect mortality and no toxic lesions were specifically induced. Furthermore, the incidence of tumours in the treated groups did not show any significant dose-related increase as compared with the control group. The results thus indicate that TAP is neither toxic nor carcinogenic for any organs or tissues of F344 rats when given continuously at levels of 125 or 250 ppm in drinking water for 2 yr. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：1075 / 1080

页数：6

共 50 条

[41] LONG-TERM CARCINOGENICITY BIOASSAY OF THE HERBICIDE ATRAZINE IN F344 RATS
PINTER, A
TOROK, G
BORZSONYI, M
SURJAN, A
CSIK, M
KELECSENYI, Z
KOCSIS, Z
MUTATION RESEARCH, 1990, 234 (06): : 398 - 398
[42] Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats
Min Gi
Masaki Fujioka
Shotaro Yamano
Anna Kakehashi
Yuji Oishi
Takahiro Okuno
Nao Yukimatsu
Takashi Yamaguchi
Yoshiyuki Tago
Mistuaki Kitano
Shim-mo Hayashi
Hideki Wanibuchi
Archives of Toxicology, 2018, 92 : 3565 - 3583
[43] LACK OF EVIDENCE OF CARCINOGENICITY OF TECHNICAL-GRADE PIPERONYL BUTOXIDE IN F344 RATS - SELECTIVE INDUCTION OF ILEOCECAL ULCERS
MAEKAWA, A
ONODERA, H
FURUTA, K
TANIGAWA, H
OGIU, T
HAYASHI, Y
FOOD AND CHEMICAL TOXICOLOGY, 1985, 23 (07) : 675 - 682
[44] SPONTANEOUS CALCIFICATION IN F344/SLC AND F344/JCL RATS
IMAI, S
MORIMOTO, J
KIYOZUKA, Y
SHIMA, M
NAKAMORI, K
TSUBURA, Y
EXPERIMENTAL ANIMALS, 1986, 35 (04) : 521 - 525
[45] Carcinogenicity of glycidol in F344 rats and B6C3F mice
Irwin, RD
Eustis, SL
Stefanski, S
Haseman, JK
JOURNAL OF APPLIED TOXICOLOGY, 1996, 16 (03) : 201 - 209
[46] Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay
Lee, I. P.
Kang, B. H.
Roh, J. K.
Kim, J. R.
FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (01) : 87 - 95
[47] Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats
Furukawa, F
Nishikawa, A
Ishiwata, H
Takahashi, M
Hayashi, Y
Hirose, M
JAPANESE JOURNAL OF CANCER RESEARCH, 2000, 91 (02): : 139 - 147
[48] EFFECTS OF ETHANOL-CONSUMPTION ON THE METABOLISM AND CARCINOGENICITY OF N'-NITROSONORNICOTINE IN F344 RATS
TRUSHIN, N
CASTONGUAY, A
RIVENSON, A
HECHT, SS
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1984, 435 (DEC) : 214 - 218
[49] THE EFFECT OF SUBSTITUENTS IN THE AROMATIC RING ON CARCINOGENICITY OF N-NITROSOMETHYLANILINE IN F344 RATS
KROEGERKOEPKE, MB
REUBER, MD
IYPE, PT
LIJINSKY, W
MICHEJDA, CJ
CARCINOGENESIS, 1983, 4 (02) : 157 - 160
[50] 2-YEAR CARCINOGENICITY STUDY OF 6-MERCAPTOPURINE IN F344 RATS
MAEKAWA, A
NAGAOKA, T
ONODERA, H
MATSUSHIMA, Y
TODATE, A
SHIBUTANI, M
OGASAWARA, H
KODAMA, Y
HAYASHI, Y
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1990, 116 (03) : 245 - 250

← 1 2 3 4 5 →