Lack of carcinogenicity of thiamphenicol in F344 rats

被引：10

作者：

Kitamura, T ^{[1
]}

Ando, J ^{[1
]}

Ishihara, R ^{[1
]}

Takano, S ^{[1
]}

Iijima, T ^{[1
]}

Nishimura, S ^{[1
]}

Yoshida, M ^{[1
]}

Takahashi, M ^{[1
]}

Maekawa, A ^{[1
]}

机构：

[1] Sasaki Inst, Dept Pathol, Chiyoda Ku, Tokyo 101, Japan

来源：

FOOD AND CHEMICAL TOXICOLOGY | 1997年 / 35卷 / 10-11期

关键词：

D O I：

10.1016/S0278-6915(97)00114-2

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The carcinogenicity of thiamphenicol (TAP), an antibiotic drug, was examined in Fischer 344 rats of both sexes. TAP was given ad lib. in drinking water at levels of 0 (control), 125 or 250 ppm to groups of 50 male and 50 female rats for 2 yr. The treatment did not affect mortality and no toxic lesions were specifically induced. Furthermore, the incidence of tumours in the treated groups did not show any significant dose-related increase as compared with the control group. The results thus indicate that TAP is neither toxic nor carcinogenic for any organs or tissues of F344 rats when given continuously at levels of 125 or 250 ppm in drinking water for 2 yr. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：1075 / 1080

页数：6

共 50 条

[31] LACK OF CARCINOGENICITY OF TARTRAZINE (FD AND C YELLOW NO 5) IN THE F344 RAT
MAEKAWA, A
MATSUOKA, C
ONODERA, H
TANIGAWA, H
FURUTA, K
KANNO, J
JANG, JJ
HAYASHI, Y
OGIU, T
FOOD AND CHEMICAL TOXICOLOGY, 1987, 25 (12) : 891 - 896
[32] CARCINOGENICITY AND TOXICITY TESTS ON PARA-PHENYLENEDIAMINE IN F344 RATS
IMAIDA, K
ISHIHARA, Y
NISHIO, O
NAKANISHI, K
ITO, N
TOXICOLOGY LETTERS, 1983, 16 (3-4) : 259 - 269
[33] Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats
Wei, M
Wanibuchi, H
Yamamoto, S
Li, W
Fukushima, S
CARCINOGENESIS, 1999, 20 (09) : 1873 - 1876
[34] STABILITY OF FECAPENTAENE-12 AND ITS CARCINOGENICITY IN F344 RATS
SHAMSUDDIN, AM
ULLAH, A
BATEN, A
HALE, E
CARCINOGENESIS, 1991, 12 (04) : 601 - 607
[35] CARCINOGENICITY STUDIES OF SOME ANALOGS OF THE CARCINOGEN METHAPYRILENE IN F344 RATS
LIJINSKY, W
KOVATCH, RM
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 1986, 112 (01) : 57 - 60
[36] Chronic toxicity and carcinogenicity of dietary administered ammonium sulfate in F344 rats
Ota, Y
Hasumura, M
Okamura, M
Takahashi, A
Ueda, M
Onodera, H
Imai, T
Mitsumori, K
Hirose, M
FOOD AND CHEMICAL TOXICOLOGY, 2006, 44 (01) : 17 - 27
[37] Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats
Gi, Min
Fujioka, Masaki
Yamano, Shotaro
Kakehashi, Anna
Oishi, Yuji
Okuno, Takahiro
Yukimatsu, Nao
Yamaguchi, Takashi
Tago, Yoshiyuki
Kitano, Mistuaki
Hayashi, Shim-mo
Wanibuchi, Hideki
ARCHIVES OF TOXICOLOGY, 2018, 92 (12) : 3565 - 3583
[38] LONG-TERM CARCINOGENICITY BIOASSAY OF THE HERBICIDE ATRAZINE IN F344 RATS
PINTER, A
TOROK, G
BORZSONYI, M
SURJAN, A
CSIK, M
KELECSENYI, Z
KOCSIS, Z
NEOPLASMA, 1990, 37 (05) : 533 - 544
[39] CARCINOGENICITY AND CHRONIC TOXICITY OF 2,4-TOLUENEDIAMINE IN F344 RATS
CARDY, RH
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1979, 62 (04) : 1107 - 1116
[40] CARCINOGENICITY OF 4-METHOXYPHENOL AND 4-METHYLCATECHOL IN F344 RATS
ASAKAWA, E
HIROSE, M
HAGIWARA, A
TAKAHASHI, S
ITO, N
INTERNATIONAL JOURNAL OF CANCER, 1994, 56 (01) : 146 - 152

← 1 2 3 4 5 →