An efficient stereoselective synthesis of functionalized vinyl ethers

被引：2

作者：

Balalaie, Saeed ^{[1
]}

Kassaee, Mohammad Z. ^{[2
]}

Bijanzadeh, Hamid Reza ^{[1
]}

Darvish, Fatemeh ^{[1
]}

Bararjanian, Morteza ^{[1
]}

Jalaiyan, Fatemeh ^{[1
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran

[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2014年 / 11卷 / 05期

基金：

美国国家科学基金会;

关键词：

Functionalized vinyl ethers; Nucleophilic addition to active alkynes; Ugi-4CR; Ugi-4CR post-transformation; N-substituted; 2-alkynamides; SUBSTITUTION; ALCOHOLS; ESTERS;

D O I：

10.1007/s13738-014-0418-6

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient regio and stereoselective synthesis of functionalized E-vinyl ethers are described. The reaction could proceed via addition of primary alcohols and phenols to functionalized N-substituted 2-alkynamides which are produced via Ugi-4CR in the presence of triethylamine at room temperature. The reaction proceeds through sequential Ugi/nucleophilic reaction sequence. High yields, short reaction times, and simple operations are the advantages of this approach.

引用

页码：1483 / 1492

页数：10

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