A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

被引：86

作者：

Cao, Shuhua ^{[1
,2
]}

Fan, Jiangli ^{[2
]}

Sun, Wen ^{[2
]}

Li, Fahui ^{[3
]}

Li, Kaoxue ^{[1
]}

Tai, Xishi ^{[1
]}

Peng, Xiaojun ^{[2
]}

机构：

[1] Weifang Univ, Coll Chem Chem & Environm Engn, 5147 Dongfeng St, Weifang 261061, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

[3] Weifang Med Univ, Sch Pharm, 7166 Baotong St, Weifang 261053, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期

基金：

美国国家科学基金会;

关键词：

PHOTODYNAMIC THERAPY; APOPTOSIS; NETWORK;

D O I：

10.1039/c9cc06040e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.

引用

页码：12956 / 12959

页数：4

共 50 条

[41] A pH/GSH Dual-Responsive Triple Synergistic Bimetallic Nanocatalyst for Enhanced Tumor Chemodynamic Therapy
Zhang, Lu
Shen, Huan
Liu, Tingting
Li, Bin
Chen, Xi
Wang, Hong
He, Chenyang
Liu, Yang
Cao, Gang
Yu, Shuo
SMALL, 2025, 21 (08)
[42] Dual-responsive and NIR-driven free radical nanoamplifier with glutathione depletion for enhanced tumor-specific photothermal/thermodynamic/chemodynamic synergistic Therapy
Chen, Fanghui
Zhang, Xichen
Wang, Zining
Xu, Chensen
Hu, Jinzhong
Liu, Ling
Zhou, Jiancheng
Sun, Baiwang
BIOMATERIALS SCIENCE, 2022, 10 (20) : 5912 - 5924
[43] Multifunctional carbon quantum dots as a theranostic nanomedicine for fluorescence imaging-guided glutathione depletion to improve chemodynamic therapy
Li, Jun
Hu, Zu-E
We, Yun-Jie
Liu, Yan-Hong
Wang, Na
Yu, Xiao-Qi
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2022, 606 : 1219 - 1228
[44] Benzoperylene-grafted and Cu2+ chelated polymeric nanoparticles for GSH depletion and chemodynamic therapy
Niu, Niu
Zhou, Huipeng
Yang, Na
Wang, Dong
Yu, Cong
MATERIALS CHEMISTRY FRONTIERS, 2021, 5 (05) : 2442 - 2451
[45] Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion
Cao, Guodong
Cao, Wei
Zhang, Jiawei
Chen, Qing
Chen, Junjie
Chu, Qiang
Sun, Qiang
Xiong, Maoming
Chen, Bo
Li, Xiang
NANO RESEARCH, 2023,
[46] Insight into the catalytic performance and reaction routes for toluene total oxidation over facilely prepared Mn-Cu bimetallic oxide catalysts
Li, Jian-Rong
Zhang, Wan-Peng
Li, Chang
Xiao, Hang
He, Chi
APPLIED SURFACE SCIENCE, 2021, 550
[47] Mesothelin targeted nano-system enhanced chemodynamic therapy and tirapazamine chemotherapy via lactate depletion
Guodong Cao
Wei Cao
Jiawei Zhang
Qing Chen
Junjie Chen
Qiang Chu
Qiang Sun
Maoming Xiong
Bo Chen
Xiang Li
Nano Research, 2023, 16 (5) : 7108 - 7118
[48] Cu2+-Pyropheophorbide a-Cystine Conjugate: Synergistic Photodynamic/Chemodynamic Therapy and Glutathione Depletion Improves the Antitumor Efficacy and Downregulates the Hypoxia-Inducing Factor
Su, Zhongping
Xu, Haiying
Zhang, Hui
Jin, Siran
Yang, Ziqing
Yan, Rui
Wang, Zhiqiang
Wu, Xiaodan
Jin, Yingxue
BIOCONJUGATE CHEMISTRY, 2023, 34 (07) : 1336 - 1347
[49] Cu2+-Citrate-Chitosan Complex Nanoparticles for the Chemodynamic Therapy of Lung Cancer
Sun, Hechen
Zhang, Lening
Zhao, Nan
Xin, Hua
ACS OMEGA, 2024, 9 (07): : 8425 - 8433
[50] Bimetallic nanozyme of Cu-Mn organophyllosilicate with enhanced multi-enzyme mimetic activity for simultaneous degradation of hydroquinone and methylene blue
Lv, Rui
He, Beibei
Sun, Shiyong
Wang, Ke
Lin, Sen
Kotova, Elena Leonidovna
Liu, Jin
Tang, Haoming
ENVIRONMENTAL SCIENCE-NANO, 2024, 11 (11) : 4606 - 4620

← 1 2 3 4 5 →