A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

被引：86
|
作者：
Cao, Shuhua [1 ,2 ]
Fan, Jiangli [2 ]
Sun, Wen [2 ]
Li, Fahui [3 ]
Li, Kaoxue [1 ]
Tai, Xishi [1 ]
Peng, Xiaojun [2 ]
机构：
[1] Weifang Univ, Coll Chem Chem & Environm Engn, 5147 Dongfeng St, Weifang 261061, Peoples R China
[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
[3] Weifang Med Univ, Sch Pharm, 7166 Baotong St, Weifang 261053, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期
基金：
美国国家科学基金会;
关键词：
PHOTODYNAMIC THERAPY; APOPTOSIS; NETWORK;
D O I：
10.1039/c9cc06040e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.
引用
收藏
页码：12956 / 12959
页数：4
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