A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

被引：86
|
作者：
Cao, Shuhua [1 ,2 ]
Fan, Jiangli [2 ]
Sun, Wen [2 ]
Li, Fahui [3 ]
Li, Kaoxue [1 ]
Tai, Xishi [1 ]
Peng, Xiaojun [2 ]
机构：
[1] Weifang Univ, Coll Chem Chem & Environm Engn, 5147 Dongfeng St, Weifang 261061, Peoples R China
[2] Dalian Univ Technol, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China
[3] Weifang Med Univ, Sch Pharm, 7166 Baotong St, Weifang 261053, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 86期
基金：
美国国家科学基金会;
关键词：
PHOTODYNAMIC THERAPY; APOPTOSIS; NETWORK;
D O I：
10.1039/c9cc06040e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A bimetallic complex, containing Mn(ii) and Cu(ii) moieties, was synthesized for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a hydroxyl radical (OH) via a Fenton-like reaction involving a Mn complex, and simultaneously depleting glutathione via a Cu complex induced oxidative reaction, thereby enhancing the efficiency of CDT.
引用
收藏
页码：12956 / 12959
页数：4
相关论文
共 50 条
  • [1] Facile synthesis of intelligent semi-salamo Cu (II) complex with glutathione depletion for enhanced chemodynamic therapy
    Guo, Wenting
    Ma, Yan
    Ji, Tongxin
    Bai, Dongzhen
    Yang, Rui
    He, Yunzhao
    Song, Heyuan
    Dong, Wenkui
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1314
  • [2] Novel strategies of glutathione depletion in photodynamic and chemodynamic therapy: A review
    Wolny, Daniel
    Stojko, Mateusz
    Zajdel, Alicja
    ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE, 2024,
  • [3] A simultaneously GSH-depleted bimetallic Cu(II) complex for enhanced chemodynamic cancer therapy
    Cao, Shuhua
    Li, Xuezhao
    Gao, Yong
    Li, Fahui
    Li, Kaoxue
    Cao, Xuanxuan
    Dai, Yiwen
    Mao, Lirong
    Wang, Shanshan
    Tai, Xishi
    DALTON TRANSACTIONS, 2020, 49 (34) : 11851 - 11858
  • [4] Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC
    Wenting Chen
    Fangfang Hu
    Qian Gao
    Caiyun Zheng
    Que Bai
    Jinxi Liu
    Na Sun
    Wenhui Zhang
    Yanni Zhang
    Kai Dong
    Tingli Lu
    Journal of Nanobiotechnology, 22
  • [5] Tumor acidification and GSH depletion by bimetallic composite nanoparticles for enhanced chemodynamic therapy of TNBC
    Chen, Wenting
    Hu, Fangfang
    Gao, Qian
    Zheng, Caiyun
    Bai, Que
    Liu, Jinxi
    Sun, Na
    Zhang, Wenhui
    Zhang, Yanni
    Dong, Kai
    Lu, Tingli
    JOURNAL OF NANOBIOTECHNOLOGY, 2024, 22 (01)
  • [6] Multifunctional nanoparticles for enhanced sonodynamic-chemodynamic immunotherapy with glutathione depletion
    Song, Jianying
    Tang, Cong
    Wang, Yun
    Ba, Junli
    Liu, Kairui
    Gao, Jinwei
    Chang, Jin
    Kang, Jun
    Yin, Linling
    NANOMEDICINE, 2024, 19 (02) : 145 - 161
  • [7] A glutathione-activatable nanoplatform for enhanced photodynamic therapy with simultaneous hypoxia relief and glutathione depletion
    Liu, Furong
    Gong, Songlin
    Shen, Meiling
    He, Tao
    Liang, Xiuqi
    Shu, Yaqian
    Wang, Xinxin
    Ma, Shuang
    Li, Xinchao
    Zhang, Miaomiao
    Wu, Qinjie
    Gong, Changyang
    CHEMICAL ENGINEERING JOURNAL, 2021, 403 (403)
  • [8] Fenton-like reaction and glutathione depletion by chiral manganese dioxide nanoparticles for enhanced chemodynamic therapy and chemotherapy
    Gao, Fangli
    Sun, Mengmeng
    Zhang, Jie
    Chang, Yi
    Gao, Weihua
    Ma, Guanglei
    Ma, Xiaoming
    Guo, Yuming
    JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2022, 616 : 369 - 378
  • [9] Tumor-Specific Expansion of Oxidative Stress by Glutathione Depletion and Use of a Fenton Nanoagent for Enhanced Chemodynamic Therapy
    Chen, Qiufang
    Zhou, Jun
    Chen, Zhe
    Luo, Qing
    Xu, Jian
    Song, Guanbin
    ACS APPLIED MATERIALS & INTERFACES, 2019, 11 (34) : 30551 - 30565
  • [10] Copper(ii) complex enhanced chemodynamic therapy through GSH depletion and autophagy flow blockade
    Shen, Wen-Ying
    Jia, Chun-Peng
    Liao, Li-Yi
    Chen, Liu-Lin
    Yuan, Cheng-Cheng
    Gu, Yun-Qiong
    Liu, Yang-Han
    Liang, Hong
    Chen, Zhen-Feng
    DALTON TRANSACTIONS, 2023, 52 (11) : 3287 - 3294
12345