Three-Component Reaction Using the Bestmann-Ohira Reagent: A Regioselective Synthesis of Phosphonyl Pyrazole Rings

被引：112
|
作者：
Mohanan, Kishor [1 ,2 ]
Martin, Anthony R. [1 ,2 ]
Toupet, Loic [3 ]
Smietana, Michael [1 ,2 ]
Vasseur, Jean-Jacques [1 ,2 ]
机构：
[1] Univ Montpellier 1, CNRS, Inst Biomol Max Mousseron, UMR 5247, F-34095 Montpellier, France
[2] Univ Montpellier 2, F-34095 Montpellier, France
[3] Univ Rennes 1, CNRS, Inst Phys IPR, UMR 6521, F-35042 Rennes, France
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 18期
关键词：
click chemistry; cycloaddition; heterocycles; multicomponent reactions; phosphonates; BASE-MEDIATED REACTION; 1,3-DIPOLAR CYCLOADDITIONS; MULTICOMPONENT REACTIONS; CARBONYL-COMPOUNDS; TERMINAL ALKYNES; NATURAL-PRODUCTS; DOMINO REACTIONS; NUCLEOSIDES; DERIVATIVES; GENERATION;
D O I：
10.1002/anie.200906781
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
BOR-n to run: A new one-pot multicomponent reaction involving the use of an aldehyde, a cyanoacid derivative, and the Bestmann-Ohira reagent (BOR) has been developed for the synthesis of substituted phosphonyl pyrazoles. This process was also combined with a copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition to generate five new bonds and two heterocyclic rings in a one-pot fashion. "Chemical Equation Presented" © 2010 Wiley-VCH Verlag GmbH S. Co. KGaA,.
引用
收藏
页码：3196 / 3199
页数：4
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