Synthesis of thioesters using an electrochemical three-component reaction involving elemental sulfur

被引：1

作者：

Liu, Gongbo ^{[1
]}

Xu, Shuoyu ^{[1
]}

Yue, Yangyang ^{[1
]}

Su, Changhui ^{[1
]}

Song, Wangze ^{[1
]}

机构：

[1] Dalian Univ Technol, Canc Hosp, Sch Chem, Sch Chem Engn, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2024年 / 60卷 / 48期

基金：

中国国家自然科学基金;

关键词：

ORGANOCATALYZED ANODIC-OXIDATION; ALPHA-KETO ACIDS; ACYLATION;

D O I：

10.1039/d4cc01910e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An electrochemical three-component reaction involving elemental sulfur is disclosed for achieving a metal-free, oxidant-free synthesis of thioesters in a high atom-economical, step-economical and chemoselective manner. A mechanistic investigation indicates that the use of elemental sulfur to trap acyl radical derived from radical umpolung of alpha-keto acid with an electrochemical design can efficiently generate a carbonyl thiyl radical, which can further be captured by diazoalkane to afford various thioesters. An electrochemical three-component reaction involving elemental sulfur is disclosed for achieving a metal-free, oxidant-free synthesis of thioesters in a high atom-economical, step-economical and chemoselective manner.

引用

页码：6154 / 6157

页数：4

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