How Autophagy Saves Mice: A Cell-Autonomous Defense System against Sindbis Virus Infection

被引：8

作者：

Yoshimori, Tamotsu ^{[1
]}

机构：

[1] Osaka Univ, Dept Cellular Regulat, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan

来源：

CELL HOST & MICROBE | 2010年 / 7卷 / 02期

关键词：

DISEASE;

D O I：

10.1016/j.chom.2010.02.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Autophagy has diverse roles, including defense against infection. Levine and colleagues (Orvedahl et al., 2010) provide in vivo evidence for the antiviral function of autophagy in vertebrates: autophagy protects mice against lethal Sindbis virus CNS infection by degrading viral proteins whose accumulation would otherwise cause neuronal cell death.

引用

页码：83 / 84

页数：2

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