How Autophagy Saves Mice: A Cell-Autonomous Defense System against Sindbis Virus Infection

被引：8
|
作者：
Yoshimori, Tamotsu [1 ]
机构：
[1] Osaka Univ, Dept Cellular Regulat, Microbial Dis Res Inst, Suita, Osaka 5650871, Japan
来源：
CELL HOST & MICROBE | 2010年 / 7卷 / 02期
关键词：
DISEASE;
D O I：
10.1016/j.chom.2010.02.003
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Autophagy has diverse roles, including defense against infection. Levine and colleagues (Orvedahl et al., 2010) provide in vivo evidence for the antiviral function of autophagy in vertebrates: autophagy protects mice against lethal Sindbis virus CNS infection by degrading viral proteins whose accumulation would otherwise cause neuronal cell death.
引用
收藏
页码：83 / 84
页数：2
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