Relationship of single nucleotide polymorphisms and haplotype interaction of mitochondrial unfolded protein response pathway genes with head and neck cancer

被引：11
|
作者：
Ahmed, Malik Waqar [1 ]
Mahjabeen, Ishrat [1 ]
Gul, Shazma [1 ]
Khursheed, Anum [1 ]
Mehmood, Azhar [1 ]
Kayani, Mahmood Akhtar [1 ]
机构：
[1] COMSATS Univ Islamabad, Dept Biosci, Canc Genet & Epigenet Lab, Pk Rd Tarlai Kalan, Islamabad, Pakistan
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 33期
关键词：
clinical outcome; haplotype analysis; HNC; metastasis; UPRmt mechanism;
D O I：
10.2217/fon-2019-0365
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: In this study, we evaluated the effect of selected polymorphisms of mitochondrial unfolded protein response (UPRmt) pathway in 500 head and neck cancer (HNC) patients and 500 healthy controls from Pakistan. Materials & methods: The experiments were conducted using tetra-ARMS PCR followed by DNA sequencing. Results: Multivariate analysis showed that AA genotype of rs3782116 showed fivefold, GG genotype of rs6598072 approximately twofold and CC genotype of rs4946936 and TT genotype of rs12212067 showed twofold increased risk of HNC. Furthermore, haplotype analysis showed that certain haplotypes of UPRmt pathway single nucleotide polymorphisms have significant association with increased HNC risk. Conclusion: These results show that genetic aberrations in UPRmt pathway genes have association with increased HNC risk and can be an indicator of advance clinical outcome especially invasion and metastasis.
引用
收藏
页码：3819 / 3829
页数：11
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