Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer

被引：0
|
作者：
Orata, Hiroaki [1 ]
Yahata, Tetsuro [1 ]
Quan, Jinhua [1 ]
Sekine, Masayuki [1 ]
Tanaka, Kenichi [1 ]
机构：
[1] Niigata Univ, Grad Sch Med & Dent Sci, Dept Obstet & Gynecol, Div Mol Genet, Niigata 9518510, Japan
来源：
ANTICANCER RESEARCH | 2006年 / 26卷 / 3B期
关键词：
drug resistance gene; MRP1; SNP; ovarian cancer; chemotherapy;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: Single nucleotide polymorphisms (SNPs) may show clinicopathological importance as prognostic markers. This study examined the association of SNPs and the expression of drug resistance-associated markers with response to chemotherapy in advanced ovarian cancer (stages III and IV) patients. Materials and Methods: SNPs were analyzed for MDR1, MRP1, MRP2 and LRP in 60 advanced ovarian cancer patients. The protein expression of each factor was analyzed by immunohistochemistry in all patients. Results: As a result of examining the relevance of SNP genotypes to the response to chemotherapy, a significant relevance (p=0.01) was observed regarding MRP1 exon-17 SNP (G2168A) involving amino acid substitution. No significant relationship was observed between protein expression and the response to chemotherapy or disease-free survival time. Conclusion: Analysis of drug resistance gene polymorphism appears to be an indicator of the response to chemotherapy in advanced ovarian cancer.
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收藏
页码：2227 / 2232
页数：6
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