Rhythmoinotropic Myocardial Reactions in Rats with Postinfarction Cardiosclerosis against the Background of Streptozotocin-Induced Diabetes

被引：2
|
作者：
Kondtratieva, D. S. [1 ]
Afanasiev, S. A. [1 ]
Rebrova, T. Yu. [1 ]
Tsapko, L. P. [1 ]
Karpov, R. S. [1 ]
机构：
[1] Russian Acad Med Sci, Inst Cardiol, Tomsk Res Ctr, Siberian Div, Moscow 109801, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2009年 / 148卷 / 02期
关键词：
rhythmoinotropic reaction; diabetes; postinfarction cardiosclerosis; sarcoplasmic reticulum; HEART-FAILURE; RYANODINE RECEPTOR;
D O I：
10.1007/s10517-009-0675-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied rhythmoinotropic reactions of the myocardium in rats with postinfarction cardiosclerosis and in rats with postinfarction cardiosclerosis against the background of streptozotocin-induced diabetes. Inotropic myocardial response in rats with postinfarction cardiosclerosis was significantly inhibited after rest periods, while in streptozotocin diabetic rats the rhythmoinotropic myocardial reaction was comparable with the reaction of intact myocardium. The combination of postinfarction cardiosclerosis and diabetes paradoxically contributed to preservation of contractile function of the myocardium in rats.
引用
收藏
页码：181 / 183
页数：3
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