Plasma miR-30a-5p as an early novel noninvasive diagnostic and prognostic biomarker for lung cancer

被引：8
|
作者：
Liang, Ling-Bo [1 ,2 ]
Zhu, Wen-Jun [3 ]
Chen, Xue-Mei [4 ]
Luo, Feng-Ming [3 ]
机构：
[1] Sichuan Univ, Div Gen Practice, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, Sect Pedag Res Gen Practice, West China Hosp, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Res Core Facil, Chengdu 610041, Sichuan, Peoples R China
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 32期
关键词：
diagnosis; MiR-30a-5p; non-small-cell lung cancer; prognosis; MICRORNAS; CARCINOMA; GENOMICS;
D O I：
10.2217/fon-2019-0393
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Circulation miRNAs have become increasingly appreciated in the diagnosis and prognosis of lung cancer. This study aims to identify and evaluate plasma miRNA-30a-5p as an early noninvasive biomarker for the diagnosis and prognosis of lung cancer. Pateints & methods: Expression levels of plasma miRNA 30a-5p were measured by quantitative real-time PCR. Receiver operating characteristic analysis and area under the curve were used to differentiate malignant from benign tumors and from healthy controls. Kaplan-Meier curves and Cox regression were used to determine survival and prognosis. Results: Our results suggest that the level of miRNA-30a-5p in plasma might be a considerable early novel noninvasive diagnostic and prognostic biomarker for lung cancer. Conclusion: Prospective studies must be performed to confirm this new early novel noninvasive diagnostic and prognostic biomarker for lung cancer.
引用
收藏
页码：3711 / 3721
页数：11
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